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非模式植物中的新一代功能蛋白质组学:用于分析蛋白质复合物和翻译后修饰的技术和应用综述。

Next generation functional proteomics in non-model plants: A survey on techniques and applications for the analysis of protein complexes and post-translational modifications.

机构信息

Center for Proteomics, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.

出版信息

Phytochemistry. 2011 Jul;72(10):1192-218. doi: 10.1016/j.phytochem.2011.01.003. Epub 2011 Feb 21.

Abstract

The congruent development of computational technology, bioinformatics and analytical instrumentation makes proteomics ready for the next leap. Present-day state of the art proteomics grew from a descriptive method towards a full stake holder in systems biology. High throughput and genome wide studies are now made at the functional level. These include quantitative aspects, functional aspects with respect to protein interactions as well as post translational modifications and advanced computational methods that aid in predicting protein function and mapping these functionalities across the species border. In this review an overview is given of the current status of these aspects in plant studies with special attention to non-genomic model plants.

摘要

计算技术、生物信息学和分析仪器的同步发展使蛋白质组学准备好实现下一个飞跃。目前的蛋白质组学技术已经从一种描述性方法发展成为系统生物学的一个重要组成部分。高通量和全基因组研究现在都在功能层面上进行。这些研究包括定量方面、蛋白质相互作用以及翻译后修饰的功能方面,还有帮助预测蛋白质功能并在物种边界上映射这些功能的高级计算方法。在这篇综述中,特别关注非基因组模式植物,概述了这些方面在植物研究中的现状。

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