De Bandt J P, Ballet F, Cynober L, Rey C, Coudray-Lucas C, Giboudeau J
Laboratoire de Biochimie A, Hopital Saint Antoine, Paris, France.
Nutrition. 1990 Sep-Oct;6(5):363-6.
The effects of norepinephrine (NE) on hepatic amino acid exchanges were studied in the isolated perfused rat liver using a recirculating system with a medium containing amino acids at twice physiologic concentrations. Norepinephrine induced a significant decrease (25%) in portal blood flow at a concentration of 2 ng/ml (10(-8) M). The hormone also increased total hepatic amino acid uptake, essentially through a switch from glutamine release to net uptake. There was no modification in free intracellular amino acids, but glycogen was slightly decreased, and glucose production was increased. Taken as a whole, these results suggest that NE modulates hepatic protein balance.
使用含有两倍生理浓度氨基酸的介质的再循环系统，在离体灌注大鼠肝脏中研究了去甲肾上腺素（NE）对肝脏氨基酸交换的影响。去甲肾上腺素在浓度为2 ng/ml（10^(-8) M）时可使门静脉血流量显著降低（25%）。该激素还增加了肝脏对氨基酸的总摄取量，主要是通过从谷氨酰胺释放转变为净摄取来实现的。细胞内游离氨基酸没有变化，但肝糖原略有减少，葡萄糖生成增加。总体而言，这些结果表明NE可调节肝脏蛋白质平衡。
