• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Streptococcus pneumoniae isolates from middle ear fluid and nasopharynx of children with acute otitis media exhibit phase variation.从急性中耳炎患儿中耳液和鼻咽部分离的肺炎链球菌分离株表现出相变异。
J Clin Microbiol. 2011 Apr;49(4):1646-9. doi: 10.1128/JCM.01990-10. Epub 2011 Feb 23.
2
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland.冰岛健康儿童鼻咽部和中耳炎儿童中耳分离的肺炎球菌对疫苗接种的影响。
J Clin Microbiol. 2018 Nov 27;56(12). doi: 10.1128/JCM.01046-18. Print 2018 Dec.
3
Distribution of pneumococcal surface protein A families 1 and 2 among Streptococcus pneumoniae isolates from children in finland who had acute otitis media or were nasopharyngeal carriers.1型和2型肺炎球菌表面蛋白A在芬兰患有急性中耳炎或为鼻咽部携带者的儿童肺炎链球菌分离株中的分布情况。
Clin Vaccine Immunol. 2008 Oct;15(10):1555-63. doi: 10.1128/CVI.00177-08. Epub 2008 Aug 27.
4
A single nucleotide polymorphism in an IgA1 protease gene determines Streptococcus pneumoniae adaptation to the middle ear during otitis media.一个 IgA1 蛋白酶基因中的单核苷酸多态性决定了肺炎链球菌在中耳炎期间适应中耳。
Pathog Dis. 2021 Jan 9;79(1). doi: 10.1093/femspd/ftaa077.
5
Genetic characteristics of Haemophilus influenzae and Streptococcus pneumoniae isolated from children with conjunctivitis-otitis media syndrome.从患有结膜炎-中耳炎综合征的儿童中分离出的流感嗜血杆菌和肺炎链球菌的遗传特征。
J Infect Chemother. 2014 Aug;20(8):493-7. doi: 10.1016/j.jiac.2014.04.015. Epub 2014 Jun 20.
6
Role of adherence of Streptococcus pneumoniae in acute otitis media.肺炎链球菌黏附在急性中耳炎中的作用。
Pediatr Infect Dis J. 1988 Jul;7(7):476-80. doi: 10.1097/00006454-198807000-00005.
7
Pneumococcal carriage and serotype variation before and after introduction of pneumococcal conjugate vaccines in patients with acute otitis media in Switzerland.瑞士急性中耳炎患者接种肺炎球菌结合疫苗前后的肺炎球菌携带情况及血清型变异
Vaccine. 2017 Apr 4;35(15):1946-1953. doi: 10.1016/j.vaccine.2017.02.010. Epub 2017 Mar 6.
8
Predictive value of pneumococcal nasopharyngeal cultures for the assessment of nonresponsive acute otitis media in children.肺炎球菌鼻咽培养物对评估儿童无反应性急性中耳炎的预测价值。
Pediatr Infect Dis J. 2000 Apr;19(4):298-303. doi: 10.1097/00006454-200004000-00007.
9
Genomic subtraction followed by dot blot screening of Streptococcus pneumoniae clinical and carriage isolates identifies genetic differences associated with strains that cause otitis media.通过基因组消减技术，随后对肺炎链球菌临床分离株和携带分离株进行斑点印迹筛选，可鉴定出与引起中耳炎的菌株相关的基因差异。
Infect Immun. 2005 May;73(5):2805-11. doi: 10.1128/IAI.73.5.2805-2811.2005.
10
Correlation of higher antibody levels to pneumococcal proteins with protection from pneumococcal acute otitis media but not protection from nasopharyngeal colonization in young children.肺炎球菌蛋白抗体水平较高与幼儿预防肺炎球菌性急性中耳炎相关，但与预防鼻咽部定植无关。
Clin Microbiol Infect. 2017 Jul;23(7):487.e1-487.e6. doi: 10.1016/j.cmi.2017.01.011. Epub 2017 Jan 28.

引用本文的文献

1
Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids.针对多糖荚膜的天然抗体使库普弗细胞能够在肝血窦中捕获入侵的细菌。
J Exp Med. 2025 Feb 3;222(2). doi: 10.1084/jem.20240735. Epub 2024 Dec 24.
2
Carbon source-dependent capsule thickness regulation in .碳源依赖性荚膜厚度调节在 …… 中。
Front Cell Infect Microbiol. 2023 Nov 29;13:1279119. doi: 10.3389/fcimb.2023.1279119. eCollection 2023.
3
Population structure of ocular is highly diverse and formed by lineages that escape current vaccines.眼部的种群结构高度多样化，由逃避当前疫苗的谱系形成。
Microb Genom. 2022 Mar;8(3). doi: 10.1099/mgen.0.000763.
4
Anatomical Site-Specific Carbohydrate Availability Impacts Streptococcus pneumoniae Virulence and Fitness during Colonization and Disease.解剖部位特异性碳水化合物的可利用性影响肺炎链球菌在定植和发病过程中的毒力和适应性。
Infect Immun. 2022 Jan 25;90(1):e0045121. doi: 10.1128/IAI.00451-21. Epub 2021 Nov 8.
5
Virulence-Associated Characteristics of Serotype 14 and Serogroup 9 Clones Circulating in Brazil: Association of Penicillin Non-susceptibility With Transparent Colony Phenotype Variants.在巴西流行的14型血清型和9血清群克隆的毒力相关特征：青霉素不敏感性与透明菌落表型变体的关联
Front Microbiol. 2020 Aug 26;11:2009. doi: 10.3389/fmicb.2020.02009. eCollection 2020.
6
Comparative Analysis of Type I Restriction-Modification Loci: Variation in Gene Target Recognition Domains.I型限制修饰位点的比较分析：基因靶标识别结构域的变异
Pathogens. 2020 Aug 29;9(9):712. doi: 10.3390/pathogens9090712.
7
Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence.信号转导系统的阶段性变化控制艰难梭菌的菌落形态、运动性和毒力。
PLoS Biol. 2019 Oct 28;17(10):e3000379. doi: 10.1371/journal.pbio.3000379. eCollection 2019 Oct.
8
Subversion of host immune responses by otopathogens during otitis media.耳病原体在中耳炎期间对宿主免疫反应的颠覆。
J Leukoc Biol. 2019 Oct;106(4):943-956. doi: 10.1002/JLB.4RU0119-003R. Epub 2019 May 10.
9
TIGR4 Phase-Locked Opacity Variants Differ in Virulence Phenotypes.TIGR4锁相不透明度变体在毒力表型上存在差异。
mSphere. 2017 Nov 15;2(6). doi: 10.1128/mSphere.00386-17. eCollection 2017 Nov-Dec.
10
Anatomical site-specific contributions of pneumococcal virulence determinants.肺炎球菌毒力决定因素的解剖部位特异性作用。
Pneumonia (Nathan). 2016;8. doi: 10.1186/s41479-016-0007-9. Epub 2016 Jun 3.

本文引用的文献

1
The pneumococcus: why a commensal misbehaves.肺炎链球菌：共生菌为何行为不当。
J Mol Med (Berl). 2010 Feb;88(2):97-102. doi: 10.1007/s00109-009-0557-x. Epub 2009 Nov 7.
2
Interaction of phase variation, host and pressure/gas composition: pneumococcal gene expression of PsaA, SpxB, Ply and LytA in simulated middle ear environments.相变、宿主与压力/气体成分的相互作用：模拟中耳环境中肺炎链球菌PsaA、SpxB、Ply和LytA的基因表达
Int J Pediatr Otorhinolaryngol. 2009 Oct;73(10):1417-22. doi: 10.1016/j.ijporl.2009.07.007. Epub 2009 Aug 13.
3
Interaction of pneumococcal phase variation and middle ear pressure/gas composition: an in vitro model of simulated otitis media.肺炎球菌相变与中耳压力/气体成分的相互作用：模拟中耳炎的体外模型
Microb Pathog. 2008 Sep;45(3):201-6. doi: 10.1016/j.micpath.2008.05.004. Epub 2008 Jun 3.
4
Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance.荚膜通过限制黏液介导的清除作用增强肺炎球菌定植。
Infect Immun. 2007 Jan;75(1):83-90. doi: 10.1128/IAI.01475-06. Epub 2006 Nov 6.
5
Nasal colonization with Streptococcus pneumoniae includes subpopulations of surface and invasive pneumococci.肺炎链球菌的鼻腔定植包括表面肺炎球菌和侵袭性肺炎球菌亚群。
Infect Immun. 2005 Oct;73(10):6945-51. doi: 10.1128/IAI.73.10.6945-6951.2005.
6
Household transmission of Streptococcus pneumoniae among siblings with acute otitis media.肺炎链球菌在患有急性中耳炎的兄弟姐妹之间的家庭传播。
J Clin Microbiol. 2002 May;40(5):1851-3. doi: 10.1128/JCM.40.5.1851-1853.2002.
7
Changes in availability of oxygen accentuate differences in capsular polysaccharide expression by phenotypic variants and clinical isolates of Streptococcus pneumoniae.氧气可利用性的变化加剧了肺炎链球菌表型变异株和临床分离株在荚膜多糖表达上的差异。
Infect Immun. 2001 Sep;69(9):5430-9. doi: 10.1128/IAI.69.9.5430-5439.2001.
8
Effect of influenza A virus infection on nasopharyngeal colonization and otitis media induced by transparent or opaque phenotype variants of Streptococcus pneumoniae in the chinchilla model.甲型流感病毒感染对豚鼠模型中肺炎链球菌透明或不透明表型变体诱导的鼻咽定植和中耳炎的影响。
Infect Immun. 2001 Jan;69(1):602-6. doi: 10.1128/IAI.69.1.602-606.2001.
9
Effect of intrastrain variation in the amount of capsular polysaccharide on genetic transformation of Streptococcus pneumoniae: implications for virulence studies of encapsulated strains.肺炎链球菌荚膜多糖含量的菌株内变异对其遗传转化的影响：对荚膜菌株毒力研究的启示
Infect Immun. 1999 Jul;67(7):3690-2. doi: 10.1128/IAI.67.7.3690-3692.1999.
10
Relationship between cell surface carbohydrates and intrastrain variation on opsonophagocytosis of Streptococcus pneumoniae.肺炎链球菌细胞表面碳水化合物与菌株内调理吞噬作用变异之间的关系
Infect Immun. 1999 May;67(5):2327-33. doi: 10.1128/IAI.67.5.2327-2333.1999.

从急性中耳炎患儿中耳液和鼻咽部分离的肺炎链球菌分离株表现出相变异。

Streptococcus pneumoniae isolates from middle ear fluid and nasopharynx of children with acute otitis media exhibit phase variation.

机构信息

Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.

出版信息

J Clin Microbiol. 2011 Apr;49(4):1646-9. doi: 10.1128/JCM.01990-10. Epub 2011 Feb 23.

DOI:10.1128/JCM.01990-10
PMID:21346044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3122802/
Abstract

Pneumococcal phase variation of 37 middle ear and 31 nasopharyngeal isolates obtained from children with acute otitis media was examined in the absence of intervening culture. The fraction of the opaque colonies was significantly higher in middle ear isolates than in nasopharyngeal isolates. The difference is probably the result of the pneumococci adapting to differential selective environments.

摘要

在没有中间培养的情况下，检测了 37 株来自急性中耳炎儿童的中耳分离株和 31 株鼻咽分离株的肺炎球菌相变异。中耳分离株中不透明菌落的比例明显高于鼻咽分离株。这种差异可能是肺炎球菌适应不同选择环境的结果。