Suzuki K, Yen-Chung H, Toyota T, Goto Y, Hirata Y, Okada K
Third Department of Internal Medicine, Tohoku University School of Medicine, Seiryo-machi Aobaku Sendai.
Diabetes Res. 1990 May;14(1):21-5.
This study was carried out to clarify the relationship between the slowing of motor nerve conduction velocity and nerve levels of sorbitol, fructose, glucose and myoinositol in spontaneously diabetic GK (Goto-Kakizaki) rats. The motor nerve conduction velocity in GK rats was constantly lower than in normal controls at three and nine months of age. This constant decrease in motor nerve conduction velocity in GK rats was closely related to glucose intolerance in GK rats soon after birth. Nerve levels of sorbitol, glucose and fructose in GK rats were significantly increased as compared to normal controls at nine months old, but not (except glucose) at three months old. The increase in nerve concentrations of sugars in GK rats was progressive with age. However, levels of glucose, sorbitol and fructose in normal Wistar rats remain unchanged with age. Although nerve myo-inositol levels in GK rats were lower at three and nine months than those of normal controls, a significant difference in myo-inositol levels was observed only at nine months. On the contrary, nerve myo-inositol level in normal Wistar rats did not show age-related change. These findings suggested that both enhanced polyol pathway activity and myo-inositol depletion play important roles in the reduction of motor nerve conduction velocity.
本研究旨在阐明自发性糖尿病GK（Goto-Kakizaki）大鼠运动神经传导速度减慢与神经中山梨醇、果糖、葡萄糖和肌醇水平之间的关系。GK大鼠在3个月和9个月大时，其运动神经传导速度始终低于正常对照组。GK大鼠运动神经传导速度的持续下降与出生后不久GK大鼠的葡萄糖不耐受密切相关。与正常对照组相比，9个月大的GK大鼠神经中的山梨醇、葡萄糖和果糖水平显著升高，但3个月大时（葡萄糖除外）未升高。GK大鼠神经中糖浓度的升高随年龄增长而渐进。然而，正常Wistar大鼠的葡萄糖、山梨醇和果糖水平不会随年龄变化。虽然GK大鼠在3个月和9个月时神经肌醇水平低于正常对照组，但仅在9个月时观察到肌醇水平有显著差异。相反，正常Wistar大鼠的神经肌醇水平未显示出与年龄相关的变化。这些发现表明，多元醇途径活性增强和肌醇耗竭在运动神经传导速度降低中均起重要作用。
