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Lighting up the hypothalamus: coordinated control of feeding behavior.点亮下丘脑：摄食行为的协调控制。
Nat Neurosci. 2011 Mar;14(3):277-8. doi: 10.1038/nn0311-277.
2
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training.AGRP 神经元足以快速协调进食行为，而无需进行训练。
Nat Neurosci. 2011 Mar;14(3):351-5. doi: 10.1038/nn.2739. Epub 2010 Jan 5.
3
Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.促黑素细胞激素原（POMC）和刺鼠肽蛋白（AgRP）神经元中的核糖体S6K1调节小鼠的葡萄糖稳态，但不调节摄食行为。
Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029. Epub 2015 Apr 9.
4
Neuroscience: Dissecting appetite.神经科学：剖析食欲。
Nature. 2014 Apr 17;508(7496):S64-5. doi: 10.1038/508S64a.
5
Network of hypothalamic neurons that control appetite.控制食欲的下丘脑神经元网络。
BMB Rep. 2015 Apr;48(4):229-33. doi: 10.5483/bmbrep.2015.48.4.272.
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Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance.怀孕期间瘦素对下丘脑反应的丧失与黑素皮质素抵抗的发展有关。
J Neuroendocrinol. 2009 May;21(5):449-56. doi: 10.1111/j.1365-2826.2009.01862.x.
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Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit.下丘脑内侧基底部的亮氨酸感知通过激活下丘脑 - 脑干回路来调节食物摄入。
J Neurosci. 2009 Jul 1;29(26):8302-11. doi: 10.1523/JNEUROSCI.1668-09.2009.
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Agouti-related peptide-expressing neurons are mandatory for feeding.表达刺鼠相关肽的神经元对进食至关重要。
Nat Neurosci. 2005 Oct;8(10):1289-91. doi: 10.1038/nn1548. Epub 2005 Sep 11.
9
Sensory detection of food rapidly modulates arcuate feeding circuits.对食物的感官检测会迅速调节弓状核进食回路。
Cell. 2015 Feb 26;160(5):829-841. doi: 10.1016/j.cell.2015.01.033. Epub 2015 Feb 19.
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Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network.下丘脑室管膜细胞通过激活弓状神经元网络产生急性多食。
Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14473-14481. doi: 10.1073/pnas.1919887117. Epub 2020 Jun 8.
引用本文的文献
1
Obesity and metabolic syndrome in patients with epilepsy, their relation with epilepsy control.肥胖症和代谢综合征与癫痫患者的关系及其与癫痫控制的关系。
Ann Afr Med. 2023 Apr-Jun;22(2):136-144. doi: 10.4103/aam.aam_139_22.
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Zonisamide Therapy Reduces Metabolic Consequences and Diminishes Nonalcoholic Fatty Liver Disease in Patients with Epilepsy.唑尼沙胺治疗可减轻癫痫患者的代谢后果并改善非酒精性脂肪性肝病。
J Clin Med. 2021 Jul 30;10(15):3380. doi: 10.3390/jcm10153380.
3
Neuronal Signal Transduction-Involved Genes in Pig Hypothalamus Affect Feed Efficiency as Revealed by Transcriptome Analysis.下丘脑参与神经元信号转导的基因通过转录组分析影响猪的饲料效率。
Biomed Res Int. 2018 Dec 26;2018:5862571. doi: 10.1155/2018/5862571. eCollection 2018.
4
Appetite-Controlling Endocrine Systems in Teleosts.硬骨鱼的食欲控制内分泌系统
Front Endocrinol (Lausanne). 2017 Apr 18;8:73. doi: 10.3389/fendo.2017.00073. eCollection 2017.
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The Ontogeny and Brain Distribution Dynamics of the Appetite Regulators NPY, CART and pOX in Larval Atlantic Cod (Gadus morhua L.).大西洋鳕鱼（Gadus morhua L.）幼鱼中食欲调节因子NPY、CART和pOX的个体发育及脑部分布动态
PLoS One. 2016 Apr 21;11(4):e0153743. doi: 10.1371/journal.pone.0153743. eCollection 2016.
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Control of Body Weight by Eating Behavior in Children.儿童通过饮食行为控制体重。
Front Pediatr. 2015 Oct 19;3:89. doi: 10.3389/fped.2015.00089. eCollection 2015.
7
Obesity and deep brain stimulation: an overview.肥胖与深部脑刺激：概述
Ann Neurosci. 2015 Jul;22(3):181-8. doi: 10.5214/ans.0972.7531.220310.
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Regulation of Appetite, Body Composition, and Metabolic Hormones by Vasoactive Intestinal Polypeptide (VIP).血管活性肠肽（VIP）对食欲、身体成分和代谢激素的调节作用
J Mol Neurosci. 2015 Jun;56(2):377-87. doi: 10.1007/s12031-015-0556-z. Epub 2015 Apr 23.
9
Bariatric endocrinology: principles of medical practice.肥胖症内分泌学：医学实践原则
Int J Endocrinol. 2014;2014:917813. doi: 10.1155/2014/917813. Epub 2014 May 12.
10
Recent advances in clinical practice challenges and opportunities in the management of obesity.临床实践的最新进展——肥胖管理面临的挑战与机遇。
Gut. 2014 Apr;63(4):687-95. doi: 10.1136/gutjnl-2013-306235. Epub 2014 Jan 8.
本文引用的文献
1
GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism.AgRP 神经元的 GABA 能信号通过一种独立于黑皮质素的机制来防止厌食症。
Eur J Pharmacol. 2011 Jun 11;660(1):21-7. doi: 10.1016/j.ejphar.2010.10.110. Epub 2011 Jan 3.
2
Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network.瘦素、胰岛素和血清素对中枢黑色素皮质系统的调制：分散神经元网络中的协同作用。
Eur J Pharmacol. 2011 Jun 11;660(1):2-12. doi: 10.1016/j.ejphar.2010.11.042. Epub 2011 Jan 3.
3
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training.AGRP 神经元足以快速协调进食行为，而无需进行训练。
Nat Neurosci. 2011 Mar;14(3):351-5. doi: 10.1038/nn.2739. Epub 2010 Jan 5.
4
Mechanism of the development of obesity in animals with hypothalamic lesions.下丘脑损伤动物肥胖发生的机制。
Physiol Rev. 1946 Oct;26(4):541-59. doi: 10.1152/physrev.1946.26.4.541.
5
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.通过光遗传学控制基底神经节回路调节帕金森运动行为。
Nature. 2010 Jul 29;466(7306):622-6. doi: 10.1038/nature09159. Epub 2010 Jul 7.
6
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.AgRP神经元突触释放γ-氨基丁酸（GABA）是能量平衡正常调节所必需的。
Nat Neurosci. 2008 Sep;11(9):998-1000. doi: 10.1038/nn.2167.
7
Agouti-related peptide-expressing neurons are mandatory for feeding.表达刺鼠相关肽的神经元对进食至关重要。
Nat Neurosci. 2005 Oct;8(10):1289-91. doi: 10.1038/nn1548. Epub 2005 Sep 11.
8
Millisecond-timescale, genetically targeted optical control of neural activity.神经活动的毫秒级、基因靶向光学控制。
Nat Neurosci. 2005 Sep;8(9):1263-8. doi: 10.1038/nn1525. Epub 2005 Aug 14.
9
Diabetes, obesity, and the brain.糖尿病、肥胖与大脑。
Science. 2005 Jan 21;307(5708):375-9. doi: 10.1126/science.1104344.
10
Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice.阿片促黑皮质素原的转基因神经元表达减弱了瘦素缺乏型肥胖小鼠对禁食的贪食反应，并逆转了代谢障碍。
Diabetes. 2003 Nov;52(11):2675-83. doi: 10.2337/diabetes.52.11.2675.
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