Section of Applied Neuroendocrinology, Karolinska Institutet, Mandometer Clinic Novum , Huddinge , Sweden.
Department of Paediatric Endocrinology, School of Clinical Sciences, University of Bristol , Bristol , UK ; Department of Diabetes, School of Clinical Sciences, University of Bristol , Bristol , UK ; Department of Metabolic Endocrinology, School of Clinical Sciences, University of Bristol , Bristol , UK.
Front Pediatr. 2015 Oct 19;3:89. doi: 10.3389/fped.2015.00089. eCollection 2015.
Diet, exercise, and pharmacological interventions have limited effects in counteracting the worldwide increase in pediatric body weight. Moreover, the promise that individualized drug design will work to induce weight loss appears to be exaggerated. We suggest that the reason for this limited success is that the cause of obesity has been misunderstood. Body weight is mainly under external control; our brain permits us to eat under most circumstances, and unless the financial or physical cost of food is high, eating and body weight increase by default. When energy-rich, inexpensive foods are continually available, people need external support to maintain a healthy body weight. Weight loss can thereby be achieved by continuous feedback on how much and how fast to eat on a computer screen.
饮食、运动和药物干预对于抵抗全球儿童体重增加的效果有限。此外，个性化药物设计将有助于减肥的承诺似乎被夸大了。我们认为，这种有限成功的原因是对肥胖原因的误解。体重主要受外部控制；我们的大脑允许我们在大多数情况下进食，除非食物的经济或身体成本很高，否则进食和体重会默认增加。当高热量、廉价的食物不断供应时，人们需要外部支持来维持健康的体重。通过在计算机屏幕上不断反馈吃多少、吃多快，就可以实现减肥。
