转录诱变：原因及其在肿瘤发生中的作用。
Transcriptional mutagenesis: causes and involvement in tumour development.
机构信息
Université Paris Sud-11, Institut de Génétique et Microbiologie, CNRS UMR 8621, Bât 400, F-91405 Orsay Cedex, France.
出版信息
Nat Rev Cancer. 2011 Mar;11(3):218-27. doi: 10.1038/nrc3006.
Abstract
The majority of human cells do not multiply continuously but are quiescent or slow-replicating and devote a large part of their energy to transcription. When DNA damage in the transcribed strand of an active gene is bypassed by a RNA polymerase, they can miscode at the damaged site and produce mutant transcripts. This process is known as transcriptional mutagenesis and, as discussed in this Perspective, could lead to the production of mutant proteins and might therefore be important in tumour development.
摘要
大多数人类细胞不会连续不断地增殖，而是处于静止或缓慢复制状态，将大部分能量用于转录。当 RNA 聚合酶绕过活性基因转录链中的 DNA 损伤时，它们会在损伤部位发生误码，并产生突变的转录本。这个过程被称为转录突变，正如这篇观点文章所讨论的，它可能导致突变蛋白的产生，因此在肿瘤发生中可能很重要。
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