Palchuk Matvey B, Klumpenaar Michael, Jatkar Tarang, Zottola Ralph J, Adams William G, Abend Aaron H
Recombinant Data Corp., Newton, MA;
AMIA Annu Symp Proc. 2010 Nov 13;2010:577-81.
NDF-RT is the proposed source of drug classification information. We set out to construct a hierarchy of NDF-RT drug classes and RxNorm medications and evaluate it on medication records data. NDF-RT and RxNorm are distributed in different file formats, require different tools to manipulate and linking the two into a hierarchy is a non-trivial exercise. Medication data in RxNorm from two institutions was constrained by the hierarchy. Only 37% of records from one and 65% from another institution were accessible. We subsequently enriched the RxNorm mapping in NDF-RT by exploiting relationships between concepts for branded and generic drugs. Coverage improved dramatically to 93% for both institutions. To improve usability of the resulting hierarchy, we grouped clinical drugs by corresponding clinical drug form.
NDF-RT是拟议的药物分类信息来源。我们着手构建NDF-RT药物类别和RxNorm药物的层次结构，并在用药记录数据上对其进行评估。NDF-RT和RxNorm以不同的文件格式分发，需要不同的工具来操作，并且将两者链接成一个层次结构并非易事。来自两个机构的RxNorm中的用药数据受到该层次结构的限制。一个机构只有37%的记录以及另一个机构65%的记录可访问。随后，我们通过利用品牌药和仿制药概念之间的关系丰富了NDF-RT中的RxNorm映射。两个机构的覆盖率都大幅提高到了93%。为了提高所得层次结构的可用性，我们按相应的临床药物剂型对临床药物进行了分组。
