Payne Philip R O, Borlawsky Tara B, Stephens William, Barrett Matthew C, Nguyen-Pham Tri, Greaves Andrew W
The Ohio State University, Department of Biomedical Informatics, Columbus, OH.
AMIA Annu Symp Proc. 2010 Nov 13;2010:617-21.
Multi-site consortia have become the preferred setting for team-based translational research programs. Such consortia are able to facilitate increased breadth and depth of basic science and clinical research activities, but also present numerous challenges related to data collection, analysis, storage, and exchange. The Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC), a s a prototypical instance of such a consortia, uses numerous loosely coupled web applications to address its informatics needs. Over a decade of operations have allowed the CRC to identify usability and computational limitations relative to the preceding information management architecture. In response, the CRC has launched the TRITON project, with the ultimate objective of developing an open-source, extensible, and fully integrative translational research information management platform. In this manuscript, we describe the architecture, design processes, and initial implementation of thatplatform.
多中心联盟已成为基于团队的转化研究项目的首选环境。此类联盟能够促进基础科学和临床研究活动在广度和深度上的提升，但也带来了与数据收集、分析、存储和交换相关的诸多挑战。慢性淋巴细胞白血病（CLL）研究联盟（CRC）作为此类联盟的一个典型例子，使用了众多松散耦合的网络应用程序来满足其信息学需求。经过十多年的运作，CRC已经识别出相对于先前信息管理架构的可用性和计算局限性。作为回应，CRC启动了TRITON项目，其最终目标是开发一个开源、可扩展且完全集成的转化研究信息管理平台。在本手稿中，我们描述了该平台的架构、设计过程和初始实施情况。
