在甲状腺转录因子-1（TTF-1）阴性肺腺癌中，肝细胞核因子 4α（HNF4α）的主要表达。
The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma.
机构信息
Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Hospital, Niigata, Japan.
出版信息
Histopathology. 2011 Feb;58(3):467-76. doi: 10.1111/j.1365-2559.2011.03764.x. Epub 2011 Feb 23.
AIMS
To investigate TTF-1-negative pulmonary adenocarcinoma, focusing upon mucin production and the expression of hepatocyte nuclear factor-4α (HNF4α).
MATERIALS AND METHODS
Two hundred and sixty-two cases of pulmonary adenocarcinoma were examined histologically and immunohistochemically; TTF-1 was expressed in 222 cases (84.7%), and 40 cases (15.3%) were negative. Among TTF-1-negative cases there were 31 mucinous-type tumours, and HNF4α, MUC5AC and MUC2 were expressed in 34 cases (85%), 29 cases (72.5%) and four cases (10%), respectively. In contrast, their expression was rare in TTF-1-positive tumours. A statistically inverse correlation was confirmed between the expression of TTF-1 and that of HNF4α and MUC5AC.
CONCLUSION
Most TTF-1-negative pulmonary adenocarcinomas are mucinous lesions with the predominant expression of HNF4α and MUC5AC.
目的
研究 TTF-1 阴性肺腺癌，重点关注黏蛋白的产生和肝细胞核因子-4α（HNF4α）的表达。
材料和方法
对 262 例肺腺癌病例进行组织学和免疫组织化学检查；222 例（84.7%）表达 TTF-1，40 例（15.3%）为阴性。在 TTF-1 阴性病例中，有 31 例黏液型肿瘤，HNF4α、MUC5AC 和 MUC2 在 34 例（85%）、29 例（72.5%）和 4 例（10%）中表达。相比之下，TTF-1 阳性肿瘤中它们的表达较少。TTF-1 表达与 HNF4α 和 MUC5AC 的表达之间存在统计学上的负相关。
结论
大多数 TTF-1 阴性肺腺癌是黏液性病变，以 HNF4α 和 MUC5AC 的表达为主。
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