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检测幽门螺杆菌致溃疡菌株的分子方法

Molecular Methods for Detecting Ulcerogenic Strains of H. pylori.

作者信息

Atherton J C

机构信息

Division of Gastroenterology and Institute of Infections and Immunity, University Hospital, Nottingham, UK.

出版信息

Methods Mol Med. 1997;8:133-43. doi: 10.1385/0-89603-381-3:133.

DOI:10.1385/0-89603-381-3:133
PMID:21351029
Abstract

Certain nonconserved genotypic and phenotypic characteristics of H. pylori are associated with increased risk of peptic ulceration in the human host. These characteristics can be divided into two groups: first, those relating to vacuolating cytotoxin activity (1,2), and differences in the gene encoding the cytotoxin, vacA (3); second, those relating to the cytotoxin-associated gene, cagA (4,5).

摘要

幽门螺杆菌某些非保守的基因型和表型特征与人类宿主发生消化性溃疡的风险增加有关。这些特征可分为两组：第一组与空泡毒素活性有关（1,2），以及编码该毒素的基因vacA存在差异（3）；第二组与细胞毒素相关基因cagA有关（4,5）。

相似文献

1
Molecular Methods for Detecting Ulcerogenic Strains of H. pylori.检测幽门螺杆菌致溃疡菌株的分子方法
Methods Mol Med. 1997;8:133-43. doi: 10.1385/0-89603-381-3:133.
2
Dominant cagA/vacA genotypes and coinfection frequency of H. pylori in peptic ulcer or chronic gastritis patients in Zhejiang Province and correlations among different genotypes, coinfection and severity of the diseases.浙江省消化性溃疡或慢性胃炎患者中幽门螺杆菌的主要cagA/vacA基因型及混合感染频率，以及不同基因型、混合感染与疾病严重程度之间的相关性。
Chin Med J (Engl). 2005 Mar 20;118(6):460-7.
3
Helicobacter pylori vacA genotypes and cagA gene in a series of 383 H. pylori-positive patients.383例幽门螺杆菌阳性患者中幽门螺杆菌vacA基因型和cagA基因情况
Z Gastroenterol. 2000 Jul;38(7):559-64. doi: 10.1055/s-2000-7449.
4
Genetic analysis of the cytotoxin-associated gene and the vacuolating toxin gene in Helicobacter pylori strains isolated from Taiwanese patients.对从台湾患者分离出的幽门螺杆菌菌株中细胞毒素相关基因和空泡毒素基因的遗传分析。
Am J Gastroenterol. 1997 Aug;92(8):1316-21.
5
Relation between vacA subtypes, cytotoxin activity, and disease in Helicobacter pylori-infected patients from The Netherlands.荷兰幽门螺杆菌感染患者中vacA亚型、细胞毒素活性与疾病之间的关系。
Am J Gastroenterol. 1999 Jun;94(6):1517-21. doi: 10.1111/j.1572-0241.1999.01136.x.
6
Association of peptic ulcer with increased expression of Lewis antigens, but not vacuolating cytotoxin activity or babA2 gene status, in Helicobacter pylori strains from China.中国幽门螺杆菌菌株中消化性溃疡与Lewis抗原表达增加相关，但与空泡毒素活性或babA2基因状态无关。
Chin J Dig Dis. 2006;7(1):61-5. doi: 10.1111/j.1443-9573.2006.00246.x.
7
Analysis of the expression of CagA and VacA and the vacuolating activity in 167 isolates from patients with either peptic ulcers or non-ulcer dyspepsia.对167株来自消化性溃疡或非溃疡性消化不良患者的分离菌株中CagA和VacA的表达及空泡形成活性进行分析。
Am J Gastroenterol. 1998 Jan;93(1):30-4. doi: 10.1111/j.1572-0241.1998.030_c.x.
8
[Typification of strains of Helicobacter pylori by the detection of the cagA gene and subtypes of the vacA gene].
Enferm Infecc Microbiol Clin. 1999 Apr;17(4):171-5.
9
[Molecular detection of Helicobacter pylori vacA and cagA genes in gastric tissue specimens of patients with peptic ulcer disease and non-ulcer dyspepsia].[消化性溃疡病和非溃疡性消化不良患者胃组织标本中幽门螺杆菌vacA和cagA基因的分子检测]
Mikrobiyol Bul. 2011 Jan;45(1):11-20.
10
Significance of cagA status and vacA subtypes of Helicobacter pylori in determining gastric histopathology: virulence markers of H. pylori and histopathology.幽门螺杆菌的cagA状态和vacA亚型在确定胃组织病理学中的意义：幽门螺杆菌的毒力标志物与组织病理学
J Gastroenterol Hepatol. 2006 Jun;21(6):1042-7. doi: 10.1111/j.1440-1746.2006.04199.x.

引用本文的文献

1
Study of vacuolating cytotoxin A (vacA) genotypes of ulcerogenic and non-ulcerogenic strains of and its association with gastric disease.幽门螺杆菌致溃疡和非致溃疡菌株空泡毒素A（VacA）基因型的研究及其与胃部疾病的关联。
Saudi J Biol Sci. 2023 Dec;30(12):103867. doi: 10.1016/j.sjbs.2023.103867. Epub 2023 Nov 4.
2
Molecular characterization of Helicobacter pylori strains isolated from cynomolgus monkeys (M. fascicularis).从食蟹猴（食蟹猕猴）分离出的幽门螺杆菌菌株的分子特征
Vet Microbiol. 2005 Jun 15;108(1-2):133-9. doi: 10.1016/j.vetmic.2005.04.003.
3
Simple method for determination of the number of Helicobacter pylori CagA variable-region EPIYA tyrosine phosphorylation motifs by PCR.
通过聚合酶链反应（PCR）测定幽门螺杆菌CagA可变区EPIYA酪氨酸磷酸化基序数量的简单方法。
J Clin Microbiol. 2005 Feb;43(2):791-5. doi: 10.1128/JCM.43.2.791-795.2005.
4
Tyrosine phosphorylation of CagA from Chinese Helicobacter pylori isolates in AGS gastric epithelial cells.中国幽门螺杆菌分离株的CagA在AGS胃上皮细胞中的酪氨酸磷酸化
J Clin Microbiol. 2005 Feb;43(2):786-90. doi: 10.1128/JCM.43.2.786-790.2005.
5
Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner.幽门螺杆菌在体内和体外以Cag依赖的方式上调上皮细胞中的基质溶素（MMP-7）。
Gut. 2003 Oct;52(10):1408-13. doi: 10.1136/gut.52.10.1408.
6
Helicobacter pylori supernatants cause epithelial cytoskeletal disruption that is bacterial strain and epithelial cell line dependent but not toxin VacA dependent.幽门螺杆菌上清液会导致上皮细胞骨架破坏，这种破坏取决于细菌菌株和上皮细胞系，但不依赖于毒素VacA。
Infect Immun. 2003 Jun;71(6):3623-7. doi: 10.1128/IAI.71.6.3623-3627.2003.
7
Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele.南非幽门螺杆菌空泡毒素基因的等位基因多样性：vacA s1a基因型罕见，s2/m1等位基因自然存在。
J Clin Microbiol. 1999 Apr;37(4):1203-5. doi: 10.1128/JCM.37.4.1203-1205.1999.