南非幽门螺杆菌空泡毒素基因的等位基因多样性：vacA s1a基因型罕见，s2/m1等位基因自然存在。
Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele.
作者信息
Letley D P, Lastovica A, Louw J A, Hawkey C J, Atherton J C
机构信息
Division of Gastroenterology, University of Nottingham, Nottingham, United Kingdom.
出版信息
J Clin Microbiol. 1999 Apr;37(4):1203-5. doi: 10.1128/JCM.37.4.1203-1205.1999.
Abstract
We describe the rarity of Helicobacter pylori strains of vacuolating cytotoxin type s1a (the type most commonly associated with peptic ulceration in the United States) among black and mixed-race South Africans. We also provide the first description of a naturally occurring strain with the vacA allelic structure s2/m1.
摘要
我们描述了南非黑人和混血人种中具有空泡毒素s1a型（在美国最常与消化性溃疡相关的类型）的幽门螺杆菌菌株的罕见性。我们还首次描述了一种具有vacA等位基因结构s2/m1的天然菌株。
相似文献
1
Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele.南非幽门螺杆菌空泡毒素基因的等位基因多样性：vacA s1a基因型罕见，s2/m1等位基因自然存在。
J Clin Microbiol. 1999 Apr;37(4):1203-5. doi: 10.1128/JCM.37.4.1203-1205.1999.
2
Dominant cagA/vacA genotypes and coinfection frequency of H. pylori in peptic ulcer or chronic gastritis patients in Zhejiang Province and correlations among different genotypes, coinfection and severity of the diseases.浙江省消化性溃疡或慢性胃炎患者中幽门螺杆菌的主要cagA/vacA基因型及混合感染频率，以及不同基因型、混合感染与疾病严重程度之间的相关性。
Chin Med J (Engl). 2005 Mar 20;118(6):460-7.
3
Genetic analysis and clinical evaluation of vacuolating cytotoxin gene A and cytotoxin-associated gene A in Taiwanese Helicobacter pylori isolates from peptic ulcer patients.台湾地区消化性溃疡患者幽门螺杆菌分离株中细胞空泡毒素A基因和细胞毒素相关基因A的遗传分析与临床评估
Scand J Infect Dis. 2000;32(1):51-7. doi: 10.1080/00365540050164227.
4
Conservation of the cag pathogenicity island is associated with vacA alleles and gastroduodenal disease in South African Helicobacter pylori isolates.cag致病岛的保守性与南非幽门螺杆菌分离株中的vacA等位基因及胃十二指肠疾病相关。
Gut. 2001 Jul;49(1):11-7. doi: 10.1136/gut.49.1.11.
5
Relationship of vacA genotypes of Helicobacter pylori to cagA status, cytotoxin production, and clinical outcome.幽门螺杆菌vacA基因型与cagA状态、细胞毒素产生及临床结果的关系。
Helicobacter. 1998 Dec;3(4):241-53. doi: 10.1046/j.1523-5378.1998.08056.x.
6
Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.幽门螺杆菌空泡毒素等位基因的镶嵌现象。特定vacA类型与细胞毒素产生及消化性溃疡的关联。
J Biol Chem. 1995 Jul 28;270(30):17771-7. doi: 10.1074/jbc.270.30.17771.
7
[Analysis on the variance of vacA genotypes and their vacuolating toxin activity of Helicobacter pylori isolates in Zhejiang area].[浙江地区幽门螺杆菌分离株vacA基因型及其空泡毒素活性的方差分析]
Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Jul;26(7):520-4.
8
Regional variation among vacA alleles of Helicobacter pylori in China.中国幽门螺杆菌vacA等位基因的区域差异。
J Clin Microbiol. 2003 May;41(5):1942-5. doi: 10.1128/JCM.41.5.1942-1945.2003.
9
Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China.中国幽门螺杆菌中产生空泡毒素的流行情况及不同vacA等位基因的分布
J Infect Dis. 1998 Jul;178(1):220-6. doi: 10.1086/515601.
10
[The heterogeneity of genetic variants of Helicobacter pylori in patients with various acid-related diseases].[不同酸相关性疾病患者幽门螺杆菌基因变异的异质性]
Eksp Klin Gastroenterol. 2014(11):8-13.
引用本文的文献
1
Helicobacter pylori and gastric cancer: mechanisms and new perspectives.幽门螺杆菌与胃癌：机制及新观点
J Hematol Oncol. 2025 Jan 23;18(1):10. doi: 10.1186/s13045-024-01654-2.
2
A Genetic and Immunohistochemical Analysis of Helicobacter pylori Phenotypes and p27 Expression in Adenocarcinoma Patients in Jordan.约旦地区腺癌患者中幽门螺杆菌表型和 p27 表达的遗传及免疫组织化学分析。
J Epidemiol Glob Health. 2023 Jun;13(2):212-225. doi: 10.1007/s44197-023-00099-z. Epub 2023 Apr 18.
3
Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis.幽门螺杆菌 vacA 基因型与伊朗人群消化性溃疡的关联：系统评价和荟萃分析。
BMC Gastroenterol. 2020 Aug 14;20(1):266. doi: 10.1186/s12876-020-01406-9.
4
Infection, Virulence Genes' Distribution and Accompanying Clinical Outcomes: The West Africa Situation.感染、毒力基因分布及伴随的临床结局：西非情况。
Biomed Res Int. 2019 Dec 10;2019:7312908. doi: 10.1155/2019/7312908. eCollection 2019.
5
Helicobacter pylori Vacuolating Toxin and Gastric Cancer.幽门螺杆菌空泡毒素与胃癌。
Toxins (Basel). 2017 Oct 12;9(10):316. doi: 10.3390/toxins9100316.
6
Reciprocal impact of host factors and Helicobacter pylori genotypes on gastric diseases.宿主因素与幽门螺杆菌基因型对胃部疾病的相互影响。
World J Gastroenterol. 2015 Aug 21;21(31):9317-27. doi: 10.3748/wjg.v21.i31.9317.
7
Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study.空泡毒素基因型是胃癌和十二指肠溃疡相关幽门螺杆菌菌株的强标志物：一项配对病例对照研究。
J Clin Microbiol. 2014 Aug;52(8):2984-9. doi: 10.1128/JCM.00551-14. Epub 2014 Jun 11.
8
Detection of Helicobacter pylori in oropharyngeal lymphatic tissue with real-time PCR and assessment of its carcinogenic potential.实时聚合酶链反应检测口咽淋巴组织中的幽门螺杆菌及其致癌潜能评估。
Eur Arch Otorhinolaryngol. 2014 Feb;271(2):399-405. doi: 10.1007/s00405-013-2574-1. Epub 2013 Jun 7.
9
Eradication Treatment of Helicobacter pylori Infection: Its Importance and Possible Relationship in Preventing the Development of Gastric Cancer.幽门螺杆菌感染的根除治疗：其在预防胃癌发生中的重要性及可能的关系。
ISRN Gastroenterol. 2012;2012:935410. doi: 10.5402/2012/935410. Epub 2012 Jun 13.
10
Relationship between Helicobacter pylori virulence genes and clinical outcomes in Saudi patients.沙特患者中幽门螺杆菌毒力基因与临床结局的关系。
J Korean Med Sci. 2012 Feb;27(2):190-3. doi: 10.3346/jkms.2012.27.2.190. Epub 2012 Jan 27.
本文引用的文献
1
Molecular Methods for Detecting Ulcerogenic Strains of H. pylori.检测幽门螺杆菌致溃疡菌株的分子方法
Methods Mol Med. 1997;8:133-43. doi: 10.1385/0-89603-381-3:133.
2
Panmictic structure of Helicobacter pylori demonstrated by the comparative study of six genetic markers.通过六个遗传标记的比较研究证明幽门螺杆菌的随机交配结构
FEMS Microbiol Lett. 1998 Apr 15;161(2):231-9. doi: 10.1111/j.1574-6968.1998.tb12953.x.
3
Genetic relationship among isolates of Helicobacter pylori: evidence for the existence of a Helicobacter pylori species-complex.幽门螺杆菌分离株之间的遗传关系：幽门螺杆菌种复合体存在的证据。
FEMS Microbiol Lett. 1997 May 1;150(1):27-32. doi: 10.1111/j.1574-6968.1997.tb10345.x.
4
Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.幽门螺杆菌空泡毒素基因vacA异质性的临床和病理重要性。
Gastroenterology. 1997 Jan;112(1):92-9. doi: 10.1016/s0016-5085(97)70223-3.
5
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.cag是幽门螺杆菌的一个致病岛，编码I型特异性和疾病相关的毒力因子。
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14648-53. doi: 10.1073/pnas.93.25.14648.
6
Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure.通过多位点酶电泳对幽门螺杆菌进行群体遗传分析：广泛的等位基因多样性和重组群体结构。
J Bacteriol. 1996 Jul;178(13):3934-8. doi: 10.1128/jb.178.13.3934-3938.1996.
7
Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.幽门螺杆菌细胞毒素的基因结构及其在胃部疾病中关键作用的证据。
J Exp Med. 1994 May 1;179(5):1653-58. doi: 10.1084/jem.179.5.1653.
8
Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.幽门螺杆菌菌株中致空泡细胞毒素基因序列的差异。
J Biol Chem. 1994 Apr 8;269(14):10566-73.
9
Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.幽门螺杆菌空泡毒素等位基因的镶嵌现象。特定vacA类型与细胞毒素产生及消化性溃疡的关联。
J Biol Chem. 1995 Jul 28;270(30):17771-7. doi: 10.1074/jbc.270.30.17771.
10
Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.幽门螺杆菌肉汤培养滤液中的细胞毒性活性。
J Med Microbiol. 1988 Jun;26(2):93-9. doi: 10.1099/00222615-26-2-93.
Zotero 插件