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南非幽门螺杆菌空泡毒素基因的等位基因多样性：vacA s1a基因型罕见，s2/m1等位基因自然存在。

Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele.

作者信息

Letley D P, Lastovica A, Louw J A, Hawkey C J, Atherton J C

机构信息

Division of Gastroenterology, University of Nottingham, Nottingham, United Kingdom.

出版信息

J Clin Microbiol. 1999 Apr;37(4):1203-5. doi: 10.1128/JCM.37.4.1203-1205.1999.

DOI:10.1128/JCM.37.4.1203-1205.1999
PMID:10074554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC88677/
Abstract

We describe the rarity of Helicobacter pylori strains of vacuolating cytotoxin type s1a (the type most commonly associated with peptic ulceration in the United States) among black and mixed-race South Africans. We also provide the first description of a naturally occurring strain with the vacA allelic structure s2/m1.

摘要

我们描述了南非黑人和混血人种中具有空泡毒素s1a型（在美国最常与消化性溃疡相关的类型）的幽门螺杆菌菌株的罕见性。我们还首次描述了一种具有vacA等位基因结构s2/m1的天然菌株。

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Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele.南非幽门螺杆菌空泡毒素基因的等位基因多样性：vacA s1a基因型罕见，s2/m1等位基因自然存在。
J Clin Microbiol. 1999 Apr;37(4):1203-5. doi: 10.1128/JCM.37.4.1203-1205.1999.
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本文引用的文献

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Molecular Methods for Detecting Ulcerogenic Strains of H. pylori.检测幽门螺杆菌致溃疡菌株的分子方法
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Panmictic structure of Helicobacter pylori demonstrated by the comparative study of six genetic markers.通过六个遗传标记的比较研究证明幽门螺杆菌的随机交配结构
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Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.幽门螺杆菌空泡毒素基因vacA异质性的临床和病理重要性。
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5
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.cag是幽门螺杆菌的一个致病岛，编码I型特异性和疾病相关的毒力因子。
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Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.幽门螺杆菌细胞毒素的基因结构及其在胃部疾病中关键作用的证据。
J Exp Med. 1994 May 1;179(5):1653-58. doi: 10.1084/jem.179.5.1653.
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J Biol Chem. 1994 Apr 8;269(14):10566-73.
9
Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.幽门螺杆菌空泡毒素等位基因的镶嵌现象。特定vacA类型与细胞毒素产生及消化性溃疡的关联。
J Biol Chem. 1995 Jul 28;270(30):17771-7. doi: 10.1074/jbc.270.30.17771.
10
Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.幽门螺杆菌肉汤培养滤液中的细胞毒性活性。
J Med Microbiol. 1988 Jun;26(2):93-9. doi: 10.1099/00222615-26-2-93.