Otsubo H, Hoffman H J, Humphreys R P, Hendrick E B, Drake J M, Hwang P A, Becker L E, Chuang S H
Division of Neurosurgery, Hospital for Sick Children, Canada.
Pediatr Neurosurg. 1990;16(4-5):208-12. doi: 10.1159/000120528.
A retrospective study of 15 children with intracranial gangliogliomas and intractable seizures revealed that tumors associated with seizure were located in the temporal and frontal lobes. These patients underwent lobectomy under electrocorticography. Mesial temporal sclerosis was identified in the hippocampus of the excised temporal lobe in 7 of 13 patients with temporal lobectomies. Eleven of the 15 children were seizure-free over a mean follow-up period of 4 years. The surgical approach to gangliogliomas requires careful pre-operative evaluation, including neuroimaging and electrophysiological study to locate seizure activity. Removal of epileptogenic brain as well as the ganglioglioma is recommended to optimize seizure control.
一项针对15例患有颅内神经节胶质瘤并伴有顽固性癫痫发作的儿童的回顾性研究表明，与癫痫发作相关的肿瘤位于颞叶和额叶。这些患者在皮质电图监测下接受了叶切除术。在接受颞叶切除术的13例患者中，有7例在切除的颞叶海马体中发现了内侧颞叶硬化。15例儿童中有11例在平均4年的随访期内无癫痫发作。神经节胶质瘤的手术方法需要仔细的术前评估，包括神经影像学和电生理研究以定位癫痫活动。建议切除致痫脑区以及神经节胶质瘤以优化癫痫控制。
