Park Myung Soo, Ok Jong Sun, Sung JiDong, Kim Duk-Kyung, Han Seong Woo, Kim Tae-Eun, Kim Bum Sung, Kim Hyun-Joong, Kim Sung Hea, Kim Hyeongsu
Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 18450 Hwaseong, Republic of Korea.
Department of Nursing, College of Nursing, Konkuk University, 27478 Chungju, Republic of Korea.
Rev Cardiovasc Med. 2023 Apr 17;24(4):113. doi: 10.31083/j.rcm2404113. eCollection 2023 Apr.
Limited data is available between metabolic syndrome (MetS) and the development of peripheral arterial disease (PAD) or venous thromboembolism (VTE) in the Asian population. We investigated the incidence of PAD and VTE according to the prevalence of MetS and evaluated the impact of individual components in MetS on the development of PAD and VTE using Korean national data.
Data obtained from national health screening examinations of the Korean National Health Insurance Service from January 1, to December 31, 2009. In total, 9,927,538 participants, 7,830,602 participants were included in this study and the incidence rate of PAD and VTE was investigated retrospectively during a 7-year follow-up. Using the National Cholesterol Education Program Adult Treatment Panel III criteria, patients were placed into one of three groups depending on MetS component numbers: 0 (normal), 1-2 (Pre-MetS), or 3-5 (MetS).
The incidence rates of PAD and VTE in MetS were 2.25% and 0.71%, respectively. After multivariable adjustment, the risk of PAD was significantly associated with MetS (hazard ratio (HR) 1.45, 95% confidence interval (CI) 1.42-1.49), the risk of VTE was not associated with MetS (HR 1.01, 95% CI 0.96-1.05). When subgroup analyses were conducted according to MetS components, elevated fasting glucose (HR 1.26, 95% CI 1.23-1.27), abdominal obesity (HR 1.15, 95% CI 1.12-1.17), and elevated blood pressure (HR 1.13, 95% CI 1.12-1.15) were the most related to PAD. Abdominal obesity (HR 1.104, 95% CI 1.064-1.146) was associated with an increased risk of VTE.
MetS was significantly associated with an increased incidence rate of PAD among the general Korean population. On the other hand, MetS was not associated with the VTE incidence rate. Of the MetS components, only abdominal obesity was a significant predictor of VTE.
关于亚洲人群中代谢综合征（MetS）与外周动脉疾病（PAD）或静脉血栓栓塞症（VTE）发生之间的数据有限。我们利用韩国的全国数据，根据MetS的患病率调查了PAD和VTE的发病率，并评估了MetS各组分对PAD和VTE发生的影响。
数据来自韩国国民健康保险服务中心2009年1月1日至12月31日的全国健康筛查检查。总共9,927,538名参与者，本研究纳入了7,830,602名参与者，并对其在7年随访期间PAD和VTE的发病率进行了回顾性调查。根据美国国家胆固醇教育计划成人治疗小组第三次报告的标准，根据MetS组分数量将患者分为三组之一：0（正常）、1 - 2（代谢综合征前期）或3 - 5（代谢综合征）。
代谢综合征患者中PAD和VTE的发病率分别为2.25%和0.71%。多变量调整后，PAD风险与代谢综合征显著相关（风险比（HR）1.45，95%置信区间（CI）1.42 - 1.49），VTE风险与代谢综合征无关（HR 1.01，95% CI 0.96 - 1.05）。当根据代谢综合征组分进行亚组分析时，空腹血糖升高（HR 1.26，95% CI 1.23 - 1.27）、腹型肥胖（HR 1.15，95% CI 1.12 - 1.17）和血压升高（HR 1.13，95% CI 1.12 - 1.15）与PAD最为相关。腹型肥胖（HR 1.104，95% CI 1.064 - 1.146）与VTE风险增加相关。
在韩国普通人群中，代谢综合征与PAD发病率增加显著相关。另一方面，代谢综合征与VTE发病率无关。在代谢综合征的组分中，只有腹型肥胖是VTE的显著预测因素。
