无先兆偏头痛患者的支气管高反应性：这是炎症的新线索吗？
Bronchial hyper-reactivity in migraine without aura: is it a new clue for inflammation?
机构信息
From the Departments of Neurology, Mersin University School of Medicine, Mersin, Turkey (H. Kaleagasi and A. Özge); the Departments of Chest Diseases, Mersin University School of Medicine, Mersin, Turkey (E. Özgür and C. Özge).
出版信息
Headache. 2011 Mar;51(3):426-431. doi: 10.1111/j.1526-4610.2010.01798.x. Epub 2010 Nov 10.
OBJECTIVE
We attempted to investigate the relationship between migraine without aura (MwoA) and bronchial hyper-reactivity to postulate inflammation as an underlying mechanism in migraine.
BACKGROUND
Comorbidity of migraine and atopic diseases such as asthma has been an argument for suspected immune system dysfunction in migraineurs.
METHODS
Twenty patients with MwoA and 5 control subjects without history of atophy and asthma were included in study. Subjects with abnormal physical examination and chest radiographs were excluded. After a normal spirometry, methacholine bronchoprovocation test was performed in all subjects and controls according to 5 breath dosimeter methods.
RESULTS
Sixteen of 20 patients and 2 of 5 control subjects were women. Mean ages were 37.5 (19-56) and 33.8 (26-43) years, respectively. Methacholine bronchoprovocation test was positive in 3 patients (15%) but was normal in all controls (0%).
CONCLUSIONS
The relationship between MwoA and bronchial hyper-reactivity may help to postulate the inflammation in migraine as an underlying mechanism.
目的
我们试图研究无先兆偏头痛（MwoA）与支气管高反应性之间的关系，以假设炎症是偏头痛的潜在机制。
背景
偏头痛与哮喘等特应性疾病的共病一直是偏头痛患者免疫系统功能障碍的证据之一。
方法
本研究纳入了 20 例 MwoA 患者和 5 例无特应性和哮喘病史的对照者。排除体格检查和胸部 X 线异常的患者。所有患者和对照者均行正常肺量计检查后，根据 5 次呼吸剂量计法进行乙酰甲胆碱支气管激发试验。
结果
20 例患者中有 16 例为女性，5 例对照者中有 2 例为女性。患者的平均年龄为 37.5（19-56）岁，对照组为 33.8（26-43）岁。3 例（15%）患者乙酰甲胆碱支气管激发试验阳性，而所有对照者均正常（0%）。
结论
MwoA 与支气管高反应性之间的关系有助于假设偏头痛中的炎症是一种潜在机制。
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