偏头痛、过敏与组胺：它们之间有关联吗？
Migraine, Allergy, and Histamine: Is There a Link?
作者信息
Ferretti Alessandro, Gatto Mattia, Velardi Margherita, Di Nardo Giovanni, Foiadelli Thomas, Terrin Gianluca, Cecili Manuela, Raucci Umberto, Valeriani Massimiliano, Parisi Pasquale
机构信息
Pediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.
Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University of Rome, 00133 Rome, Italy.
出版信息
J Clin Med. 2023 May 19;12(10):3566. doi: 10.3390/jcm12103566.
The relationship between migraines and allergies is controversial. Though they are epidemiologically linked, the underlying pathophysiological connection between them remains unclear. Migraines and allergic disorders have various underlying genetic and biological causes. As per the literature, these conditions are epidemiologically linked, and some common pathophysiological pathways have been hypothesized. The histaminergic system may be the clue to understanding the correlation among these diseases. As a neurotransmitter in the central nervous system with a vasodilatory effect, histamine has a well-documented influence on the allergic response and could be involved in the pathophysiology of migraines. Histamine may influence hypothalamic activity, which may play a major role in migraines or may simply influence their severity. In both cases, antihistamine drugs could prove useful. This review examines whether the histaminergic system, particularly H3 and H4 receptors, may provide a mechanistic link between the pathophysiology of migraines and allergic disorders, two common and debilitating conditions. Identifying their connection could help identify novel therapeutic strategies.
偏头痛与过敏之间的关系存在争议。尽管它们在流行病学上有关联，但其潜在的病理生理联系仍不明确。偏头痛和过敏性疾病有多种潜在的遗传和生物学原因。根据文献，这些病症在流行病学上有关联，并且已经提出了一些共同的病理生理途径。组胺能系统可能是理解这些疾病之间相关性的线索。组胺作为中枢神经系统中具有血管舒张作用的神经递质，对过敏反应有充分记录的影响，并且可能参与偏头痛的病理生理过程。组胺可能影响下丘脑活动，而下丘脑活动可能在偏头痛中起主要作用，或者可能仅仅影响其严重程度。在这两种情况下，抗组胺药物可能都有用。本综述探讨组胺能系统，特别是H3和H4受体，是否可能在偏头痛和过敏性疾病（两种常见且使人衰弱的病症）的病理生理之间提供一种机制联系。确定它们之间的联系有助于确定新的治疗策略。
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