哮喘患者患偏头痛的风险：一项全国性队列研究。
Risk of Migraine in Patients With Asthma: A Nationwide Cohort Study.
作者信息
Peng Yi-Hao, Chen Kuan-Fei, Kao Chia-Hung, Chen Hsuan-Ju, Hsia Te-Chun, Chen Chia-Hung, Liao Wei-Chih
机构信息
From the Department of Respiratory Therapy, China Medical University (Y-HP, T-CH); Department of Respiratory Therapy, China Medical University Hospital (Y-HP); Department of Neurology, China Medical University Hospital, China Medical University, Taichung (K-FC); Department of Neurology, China Medical University Beigang Hospital, Yunlin (K-FC); Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-HK); Department of Nuclear Medicine and PET Center, China Medical University Hospital (C-HK); Management Office for Health Data, China Medical University Hospital (H-JC); and Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, China Medical University (T-CH, C-HC, W-CL), Taichung, Taiwan.
出版信息
Medicine (Baltimore). 2016 Mar;95(9):e2911. doi: 10.1097/MD.0000000000002911.
Asthma has been described as an "acephalic migraine" and "pulmonary migraine." However, no study has investigated the temporal frequency of migraine development in patients with asthma, and the results of previous studies may be difficult to generalize.We investigated the effect of asthma on the subsequent development of migraine by using a population-based data set in Taiwan.We retrieved our study sample from the National Health Insurance Research Database. Specifically, 25,560 patients aged 12 years and older with newly diagnosed asthma were identified as the asthma group, and 102,238 sex and age-matched patients without asthma were identified as the nonasthma group. Cox proportional-hazards regression models were employed to measure the risk of migraine for the asthmatic group compared with that for the nonasthmatic group.The risk of migraine in the asthmatic group was 1.45-fold higher (95% confidence interval 1.33-1.59) than that in the nonasthmatic group after adjustment for sex, age, the Charlson comorbidity index, common medications prescribed for patients with asthma, and annual outpatient department visits. An additional stratified analysis revealed that the risk of migraine remained significantly higher in both sexes and all age groups older than 20 years.Asthma could be an independent predisposing risk factor for migraine development in adults.
哮喘被描述为“无头部偏头痛”和“肺部偏头痛”。然而，尚无研究调查哮喘患者偏头痛发生的时间频率，且以往研究结果可能难以推广。我们利用台湾基于人群的数据集，研究了哮喘对后续偏头痛发生的影响。我们从国民健康保险研究数据库中获取研究样本。具体而言，25560名12岁及以上新诊断为哮喘的患者被确定为哮喘组，102238名年龄和性别匹配的无哮喘患者被确定为非哮喘组。采用Cox比例风险回归模型来衡量哮喘组与非哮喘组相比偏头痛的风险。在对性别、年龄、Charlson合并症指数、哮喘患者常用药物以及年度门诊就诊次数进行调整后，哮喘组偏头痛的风险比非哮喘组高1.45倍（95%置信区间1.33 - 1.59）。进一步的分层分析显示，20岁以上的所有性别和年龄组中，偏头痛风险仍然显著更高。哮喘可能是成人偏头痛发生的一个独立易感风险因素。
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