Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan.
J Dermatol. 2011 Jun;38(6):531-5. doi: 10.1111/j.1346-8138.2010.01052.x. Epub 2010 Oct 6.
Emollients are useful and important treatment adjuncts for patients with atopic dermatitis (AD). Heparinoid mucopolysaccharide creams or lotions are emulsion ointments for moisturizing the skin. The objective of this study was to investigate the view among adult AD patients regarding the effectiveness of emollients. We developed a questionnaire at our University Hospital to characterize how patients with AD viewed the efficacy of emollients. Patients were asked to participate prior to treatment and the questionnaire was given within 1 month of treatment. The severity of AD was graded as mild, moderate, severe or very severe. The severity scoring was performed only when the participants answered the questionnaire. Of the 110 enrolled AD patients, 103 returned the completed questionnaires. Ninety-eight patients (95.1%) used heparinoid mucopolysaccharide creams or lotions. There was a strong correlation between their view of the efficacy of the emollient and the condition of dry skin, pruritus and eczematous skin. There was a significant correlation between AD severity and the perceived efficacy of the emollient for dry skin, pruritus and eczematous skin. There was a greater sense of efficacy among patients with milder AD than in more severe AD cases. Patients who felt sufficient efficacy of the emollient for pruritus were significantly older than those who felt there was no efficacy. In addition, the age of onset of AD was significantly higher among those who felt sufficient efficacy for pruritus compared to those who felt little efficacy. We speculate that the efficacy of emollients could be demonstrated in the treatment of milder AD, but may only have partial efficacy in more severe cases. Emollient therapy might have lower efficacy for pruritus among younger or earlier onset AD patients.
保湿剂是特应性皮炎（AD）患者的有用且重要的治疗辅助手段。肝素类黏多糖乳膏或洗剂是用于滋润皮肤的乳剂软膏。本研究旨在调查成年 AD 患者对保湿剂疗效的看法。我们在我们的大学医院开发了一份问卷，以描述 AD 患者如何看待保湿剂的疗效。在治疗前，患者被要求参与，并在治疗后 1 个月内发放问卷。AD 的严重程度分为轻度、中度、重度或极重度。只有当参与者回答问卷时才进行严重程度评分。在 110 名纳入的 AD 患者中，有 103 名返回了完整的问卷。98 名患者（95.1%）使用肝素类黏多糖乳膏或洗剂。他们对保湿剂疗效的看法与皮肤干燥、瘙痒和湿疹样皮肤之间存在很强的相关性。AD 严重程度与对保湿剂改善皮肤干燥、瘙痒和湿疹样皮肤的疗效之间存在显著相关性。病情较轻的 AD 患者比病情较重的 AD 患者对保湿剂的疗效更有信心。对瘙痒感觉保湿剂有足够疗效的患者明显比感觉无疗效的患者年龄更大。此外，与感觉疗效不佳的患者相比，感觉瘙痒有足够疗效的患者 AD 的发病年龄明显更高。我们推测，保湿剂的疗效在治疗轻度 AD 中可能得到证实，但在更严重的病例中可能只有部分疗效。在年龄较小或发病较早的 AD 患者中，保湿剂治疗瘙痒的疗效可能较低。
