Institut de Biologie et Chimie des Protéines, Biologie Structurale des Complexes Macromoléculaires Bactériens, UMR 5086 CNRS Université de Lyon, Lyon, France.
FEBS J. 2011 Apr;278(8):1213-22. doi: 10.1111/j.1742-4658.2011.08037.x. Epub 2011 Feb 25.
Type IV secretion systems (T4SS) are macromolecular assemblies used by bacteria to transport material across their membranes. T4SS are generally composed of a set of twelve proteins (VirB1-11 and VirD4). This represents a dynamic machine powered by three ATPases. T4SS are widespread in pathogenic bacteria where they are often used to deliver effectors into host cells. For example, the human pathogen Helicobacter pylori encodes a T4SS, the Cag-T4SS, which mediates the injection of the toxin CagA. We review the progress made in the past decade in our understanding of T4SS architecture. We translate this new knowledge to derive an understanding of the structure of the H. pylori Cag system, and use recent protein-protein interaction data to refine this model.
IV 型分泌系统（T4SS）是细菌用于将物质穿过其细胞膜运输的大型分子组装体。T4SS 通常由一组十二个蛋白质（VirB1-11 和 VirD4）组成。这代表了一种由三个 ATP 酶驱动的动态机器。T4SS 在致病菌中广泛存在，它们经常被用于将效应物输送到宿主细胞中。例如，人类病原体幽门螺杆菌编码了一种 T4SS，即 Cag-T4SS，它介导毒素 CagA 的注入。我们回顾了过去十年中在理解 T4SS 结构方面取得的进展。我们将这些新知识转化为对幽门螺杆菌 Cag 系统结构的理解，并利用最近的蛋白质-蛋白质相互作用数据来完善这个模型。
