Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität, München, Germany.
FEBS J. 2011 Apr;278(8):1203-12. doi: 10.1111/j.1742-4658.2011.08036.x. Epub 2011 Feb 25.
Bacterial type IV secretion systems (T4SS) form supramolecular protein complexes that are capable of transporting DNA or protein substrates across the bacterial cell envelope and, in many cases, also across eukaryotic target cell membranes. Because of these characteristics, they are often used by pathogenic bacteria for the injection of host cell-modulating virulence factors. One example is the human pathogen Helicobacter pylori, which uses the Cag-T4SS to induce a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Work in recent years has shown that the Cag-T4SS exhibits marked differences in relation to other systems, both with respect to the composition of its secretion apparatus and the molecular details of its secretion mechanisms. This review describes the molecular properties of the Cag-T4SS and compares these with prototypical systems of this family of protein transporters.
细菌 IV 型分泌系统 (T4SS) 形成超分子蛋白复合物，能够将 DNA 或蛋白底物穿过细菌细胞包膜，并在许多情况下穿过真核靶细胞膜进行转运。由于这些特性，它们经常被致病菌用于注射宿主细胞调节毒力因子。一个例子是人类病原体幽门螺杆菌，它使用 Cag-T4SS 在胃上皮细胞中诱导促炎反应和多种细胞骨架和基因调控效应。近年来的工作表明，Cag-T4SS 在其分泌装置的组成和分泌机制的分子细节方面与其他系统存在显著差异。这篇综述描述了 Cag-T4SS 的分子特性，并将其与该蛋白转运家族的典型系统进行了比较。
