中国大陆地区快速进展性增殖性疣状白色角化病病例报告及病因学建议。

State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, PR. China.

World J Surg Oncol. 2011 Feb 27;9:26. doi: 10.1186/1477-7819-9-26.

Proliferative verrucous leukoplakia (PVL) is a rare oral leukoplakia and has four features such as chronic proliferation, multiple occurrences, refractoriness to treatment and high rate of malignant transformation. As mentioned above, most PVL cases processed to malignancy over many years, sometimes 20 years. However, this report described a case of rapid progress, which had malignant transformation in a short period. Additionally, the aetiology of PVL was discussed and immunity was proposed as the possible cause.

增殖性疣状白斑（PVL）是一种罕见的口腔白斑病，具有慢性增殖、多发性、难治性和高恶性转化率等四个特征。如前所述，大多数 PVL 病例在多年后发生恶变，有时甚至长达 20 年。然而，本报告描述了一例快速进展的病例，其在短时间内发生了恶性转化。此外，还讨论了 PVL 的病因，并提出了免疫可能是其发病原因之一。