Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan.
Gen Hosp Psychiatry. 2011 Jan-Feb;33(1):84.e3-4. doi: 10.1016/j.genhosppsych.2010.10.004. Epub 2010 Dec 3.
Valproic acid (VPA) is a well-tolerated and effective agent for the treatment of epilepsy, bipolar disorder, and schizoaffective disorder. Several case reports have indicated that VPA may induce serious symptomatic hyperammonemia. Based on analysis of susceptible patients, several possible mechanisms and risk factors have been proposed to identify the patients at risk. Nevertheless, we report the case of a schizoaffective patient who developed severe hyperammonemia occurring after brief exposure to VPA, despite the absence of any known risk factors. Until now, early recognition of the signs and symptoms of hyperammonemia is crucial to managing this unusual adverse reaction.
丙戊酸（VPA）是一种耐受性良好且有效的治疗癫痫、双相情感障碍和分裂情感障碍的药物。有几项病例报告表明，VPA 可能会引起严重的症状性高血氨症。基于对易感患者的分析，已经提出了几种可能的机制和危险因素，以确定处于危险中的患者。然而，我们报告了一例精神分裂情感障碍患者的病例，该患者在短暂接触 VPA 后发生严重的高血氨症，尽管没有任何已知的危险因素。到目前为止，早期识别高血氨症的体征和症状对于管理这种不常见的不良反应至关重要。
