多发性硬化症患者脑脊液和中枢神经系统中存在的相关 B 细胞克隆会产生脑脊液免疫球蛋白。
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.
机构信息
Institute of Clinical Neuroimmunology, Ludwig Maximilians University, 81377 Munich, Germany.
出版信息
J Neuroimmunol. 2011 Apr;233(1-2):245-8. doi: 10.1016/j.jneuroim.2011.01.010. Epub 2011 Feb 24.
Abstract
We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF.
摘要
我们研究了三个多发性硬化症患者的脑脊液 (CSF) 中的免疫球蛋白 (Ig) 蛋白质组与 CSF 和中枢神经系统 (CNS) 组织中的 B 细胞 Ig 转录组之间的重叠部分。我们通过质谱法确定了 CSF 中的 IgG 蛋白质组，并将其与 CSF 和脑损伤的 IgG 转录组进行比较，后者通过 cDNA 克隆进行分析。在 CSF 蛋白质组中鉴定出的特征肽也可以在脑损伤和 CSF 的转录组中检测到，这为脑损伤和 CSF 中的 IgG 库之间的强烈重叠提供了证据。
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