假设：多发性硬化症脑脊液免疫球蛋白G多条带源自一个或几个免疫球蛋白G分泌细胞克隆。
Hypothesis: multiple sclerosis cerebrospinal fluid IgG multiple bands are derived from one or a few IgG secretor cell clones.
作者信息
Tourtellotte W W, Shapshak P, Staugaitis S M, Saxton R E
出版信息
Prog Clin Biol Res. 1984;146:371-8.
PMID:6718429
Abstract
Analytical IEF, immunofixation, and silver nitrate staining of mouse monoclonal, human myeloma, and multiple sclerosis (MS) oligoclonal IgG result in multiple bands. Because the IgG secreted by mouse hybridoma and multiple myeloma are the products of single clones of cells, it is reasonable to propose that MS CSF IgG multiple bands may be derived from one or a small number of clones of IgG secretors.
摘要
对小鼠单克隆、人骨髓瘤和多发性硬化症（MS）寡克隆IgG进行分析性等电聚焦、免疫固定和硝酸银染色会产生多条带。由于小鼠杂交瘤和多发性骨髓瘤分泌的IgG是单个细胞克隆的产物，因此有理由推测MS脑脊液IgG多条带可能源自一个或少数几个IgG分泌细胞克隆。
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