Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.
Neurobiol Aging. 2012 Jul;33(7):1228-36. doi: 10.1016/j.neurobiolaging.2010.12.015. Epub 2011 Feb 24.
The objective of this study was to determine the neuropathological correlates of regional medial temporal lobe volume measures on magnetic resonance imaging (MRI) in subjects with Lewy body dementia (LBD). Twenty-three autopsy-confirmed LBD cases with an MRI scan close to death (mean 1.5 years) were studied. MRI-based volumetric measures were calculated for total intracranial volume, hippocampus, entorhinal cortex, and amygdala. Quantitative neuropathological analysis of plaques, tangles, and Lewy bodies were carried out in the same regions. Spearman's rho was used to examine correlations between MRI volumes and neuropathology measures and linear regression to assess the relationship between neuropathology and MRI volumes. A significant inverse correlation was observed between normalized amygdala volume and percent area of Lewy bodies in the amygdala (r = -0.461, p = 0.035). There were no other significant correlations between regional MRI volume and measures of neuropathology. Lewy body, but not Alzheimer's disease (AD) pathology was associated with reduced amygdala volume in pathologically-verified LBD cases but neither Lewy body nor Alzheimer's disease pathology was associated with volume loss in the hippocampus or entorhinal cortex, suggesting other neuropathological factors account for atrophy in these structures in LBD.
本研究旨在确定路易体痴呆（LBD）患者磁共振成像（MRI）上内侧颞叶体积测量的神经病理学相关性。研究了 23 例经尸检证实的 LBD 病例，这些病例在接近死亡时（平均 1.5 年）进行了 MRI 扫描。计算了总颅内体积、海马体、内嗅皮层和杏仁核的 MRI 基于体积的测量值。在相同区域进行了斑块、缠结和路易体的定量神经病理学分析。使用 Spearman's rho 检验 MRI 体积和神经病理学测量值之间的相关性，使用线性回归评估神经病理学与 MRI 体积之间的关系。正常化的杏仁核体积与杏仁核内路易体的面积百分比呈显著负相关（r = -0.461，p = 0.035）。MRI 体积与神经病理学测量值之间没有其他显著相关性。在经过病理证实的 LBD 病例中，与阿尔茨海默病（AD）病理相比，只有路易体病理与杏仁核体积减小相关，但路易体和 AD 病理均与海马体或内嗅皮层的体积损失无关，这表明 LBD 中这些结构的萎缩与其他神经病理学因素有关。
