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Curr Opin Biotechnol. 2011 Jun;22(3):320-5. doi: 10.1016/j.copbio.2011.01.005. Epub 2011 Feb 23.
'Too much Carbon Monoxide for me to bear…' are the opening lyrics of the CAKE song Carbon Monoxide (from their 2004 album Pressure Chief), and while this may be the case for most living organisms, several species of bacteria both thrive on this otherwise toxic gas, and metabolize it for the production of fuels and chemicals. Indeed CO fermentation offers the opportunity to sustainably produce fuels and chemicals without impacting the availability of food resources or even farm land. Mounting commercial interest in the potential of this process has in turn triggered greater scrutiny of the molecular and genetic basis for CO metabolism, as well as the challenges associated with the implementation and operation of gas fermentation at scale.
“太多的一氧化碳让我难以承受……”是 CAKE 乐队歌曲《Carbon Monoxide》（选自他们 2004 年的专辑《Pressure Chief》）的开头歌词，虽然这对大多数生物来说可能是这样，但有几种细菌既能在这种有毒气体中茁壮成长，又能代谢它来生产燃料和化学品。事实上，CO 发酵为可持续生产燃料和化学品提供了机会，而不会影响食物资源的供应，甚至不会影响农田。对这一过程潜力的商业兴趣不断增加，反过来又促使人们更仔细地研究 CO 代谢的分子和遗传基础，以及在大规模实施和运营气体发酵方面所面临的挑战。
