[阿苯达唑对微小膜壳绦虫实验性感染及人体感染的治疗效果评估]

[Evaluation of the therapeutic effect of albendazole on experimental and human infections by Hymenolepis nana].

作者信息

Amato Neto V, Moreira A A, Ferreira G M, do Nascimento S A, Matsubara L, Campos R, Pinto P L

机构信息

Laboratório de Investigação Médica-Parasitologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brasil.

出版信息

Rev Inst Med Trop Sao Paulo. 1990 May-Jun;32(3):185-8.

PMID:2135371

Abstract

With the objective of knowing adequately the spectrum of activity of albendazole against intestinal helminthiases, we made observations regarding hymenolepiasis caused by Hymenolepis nana. Two series of investigations were carried out: a) treatment of mice with single doses of either 25 or 50 mg/kg, repeated after ten days, using as controls animals treated with 25 mg/kg of praziquantel or not treated with any antiparasitic drugs; b) treatment of adults and children with 400 mg daily for three consecutive days, repeated after ten days.

摘要

为了充分了解阿苯达唑对肠道蠕虫病的活性谱，我们对微小膜壳绦虫引起的膜壳绦虫病进行了观察。进行了两个系列的研究：a）以25或50mg/kg的单剂量治疗小鼠，十天后重复给药，使用25mg/kg吡喹酮治疗的动物或未用任何抗寄生虫药物治疗的动物作为对照；b）成人和儿童连续三天每天服用400mg，十天后重复给药。