Jagota S C
Clin Ther. 1986;8(2):226-31.
The anthelmintic activity of and patient tolerance to albendazole, a broad-spectrum anthelmintic, were studied in a multicenter trial involving 480 patients ranging in age from 2 to 60 years. The patients had single or mixed infections caused by pinworms, roundworms, hookworms, whipworms, threadworms, or tapeworms. The stools were examined by the direct method, and ova were counted by means of the Kato-Katz technique. A Graham-Scotch test was also done in patients infected with Enterobius vermicularis. Most patients received a single 400-mg dose of albendazole; adults were given two tablets, and children were given a 2% suspension. All patients with Hymenolepis nana and about half of those with Taenia infections were treated for three successive days. Patients were carefully evaluated before and after treatment to assess the efficacy and safety of the drug. After a single dose of albendazole, the cure rate was 95.3% in ascariasis, 92.2% in ancylostomiasis, 90.5% in trichuriasis, 64.9% in taeniasis, and 100% in enterobiasis. Among patients receiving 400 mg of albendazole for three days, the cure rate was 63.4% in hymenolepiasis and 86.1% in taeniasis. The drug was well tolerated, and no significant side effects were reported.
在一项涉及480名年龄在2至60岁之间患者的多中心试验中，研究了广谱驱虫药阿苯达唑的驱虫活性及患者耐受性。这些患者患有由蛲虫、蛔虫、钩虫、鞭虫、线虫或绦虫引起的单一感染或混合感染。粪便采用直接法检查，虫卵通过加藤厚涂片法计数。对感染蛲虫的患者还进行了格雷厄姆-斯科特试验。大多数患者接受单次400毫克阿苯达唑剂量；成人服用两片，儿童服用2%的混悬液。所有短小膜壳绦虫感染患者和约一半的绦虫感染患者连续治疗三天。治疗前后对患者进行仔细评估，以评估药物的疗效和安全性。单次服用阿苯达唑后，蛔虫病治愈率为95.3%，钩虫病为92.2%，鞭虫病为90.5%，绦虫病为64.9%，蛲虫病为100%。在接受400毫克阿苯达唑治疗三天的患者中，短小膜壳绦虫病治愈率为63.4%，绦虫病为86.1%。该药物耐受性良好，未报告明显副作用。
