Departament de Tecnología Química i de Tensioactius, Institut de Química Avançada de Catalunya, Consejo Superior de Investigaciones Científicas, C/Jordi Girona 18-26, 08034 Barcelona, Spain.
Colloids Surf B Biointerfaces. 2011 Jun 1;84(2):390-4. doi: 10.1016/j.colsurfb.2011.01.031. Epub 2011 Feb 26.
The characterization of different bicellar aggregates and the effects of these systems on the stratum corneum (SC) microstructure have been studied. Dynamic light scattering (DLS) and freeze fracture electron microscopy (FFEM) techniques showed that both of the systems studied, dimyristoyl-phosphatidylcholine/dihexanoyl-phosphocholine (DMPC/DHPC) and dipalmitoyl-phosphocholine (DPPC)/DHPC, were formed by small discoidal aggregates at room temperature (20°C). Treating skin with DMPC/DHPC bicelles does not affect the SC lipid microstructure, whereas bicellar systems formed by DPPC and DHPC can promote the formation of new structures in the SC lipid domains. This indicates the passage of lipids from bicelles through the SC layers and also a possible interaction of these lipids with the SC lipids. Given the absence of surfactant in the bicellar composition and the small size of these structures, the use of these smart nano-systems offers great advantages over other lipid systems for dermatological purposes. Bicelles could be promising applications as drug carriers through the skin. This contribution, based on the new biological use of bicelles, may be useful to scientists engaged in colloid science and offers a new tool for different applications in skin and cosmetic research.
已经研究了不同双锥形胶束聚集物的特性以及这些体系对角质层（SC）微观结构的影响。动态光散射（DLS）和冷冻断裂电子显微镜（FFEM）技术表明，在所研究的两种体系（二肉豆蔻酰磷脂酰胆碱/二己酰基磷脂酰胆碱（DMPC/DHPC）和二棕榈酰磷脂酰胆碱（DPPC）/DHPC）中，室温（20°C）下均形成小的盘状聚集物。用 DMPC/DHPC 双锥形胶束处理皮肤不会影响 SC 脂质的微观结构，而由 DPPC 和 DHPC 形成的双锥形胶束体系可以促进 SC 脂质区域中形成新的结构。这表明脂质从双锥形胶束穿过 SC 层传递，并且这些脂质可能与 SC 脂质相互作用。鉴于双锥形胶束组成中没有表面活性剂且这些结构的尺寸较小，因此与其他脂质体系相比，这些智能纳米体系在皮肤病学方面具有很大的优势。双锥形胶束可作为经皮药物载体具有广阔的应用前景。基于双锥形胶束的新生物学用途，这一贡献可能对从事胶体科学的科学家有用，并为皮肤和化妆品研究中的不同应用提供了新工具。
