Zeng Fan-Lin, Shen Zhi-Bin, Zhang Xin
School of Traditional Chinese Medicine of Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zhong Yao Cai. 2010 Oct;33(10):1602-5.
To study the plasma concentration and pharmacokinetics of phillyrin in Shuanghuanglian for injection in rats.
SD rats were given Shuanghuanglian for injection by iv, blood samples were collected at different time. The phillyrin concentration in plasma was determined by RP-HPLC. The parameters of pharmacokinetics were analyzed by program DAS 2.0.
The main pharmacokinetics parameters of phillyrin in rats:t1/2 (alpha) (0.44 +/- 0.06) h, t1/2 (beta) (2.77 +/- 0.36) h, V1 (0.09 +/- 0.01) L/kg, CL (0.09 +/- 0.007) L/(h x kg), AUC0-1, (5.56 +/- 0.47 mg x h/L), AUC0-infinity (6.44 +/- 0.53) mg x h/L.
Phillyrin has two compartment model in rats, the pharmacokinetics of phillyrin characteristic is a process of rapid dispatching and slow elimination in rats.
