[Study on pharmacokinetics of phillyrin in Shuanghuanglian for injection].

OBJECTIVE

To study the plasma concentration and pharmacokinetics of phillyrin in Shuanghuanglian for injection in rats.

METHODS

SD rats were given Shuanghuanglian for injection by iv, blood samples were collected at different time. The phillyrin concentration in plasma was determined by RP-HPLC. The parameters of pharmacokinetics were analyzed by program DAS 2.0.

RESULTS

The main pharmacokinetics parameters of phillyrin in rats:t1/2 (alpha) (0.44 +/- 0.06) h, t1/2 (beta) (2.77 +/- 0.36) h, V1 (0.09 +/- 0.01) L/kg, CL (0.09 +/- 0.007) L/(h x kg), AUC0-1, (5.56 +/- 0.47 mg x h/L), AUC0-infinity (6.44 +/- 0.53) mg x h/L.

CONCLUSION

Phillyrin has two compartment model in rats, the pharmacokinetics of phillyrin characteristic is a process of rapid dispatching and slow elimination in rats.