Wang Xiao-su, Bai Huai, Fan Ping, Liu Rui, Liu Yu, Liu Bing-wen
Laboratory of Genetic Disease and Perinatal Medicine, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jan;42(1):19-23.
To investigate the fatty acid-binding protein 2 gene (FABP2) Ala54Thr polymorphism and its relationship to obesity in Chinese population.
Three hundred and ninety three subjects (272 non-obese and 121 obese individuals) from a population of Chinese Han nationality in Chengdu area were studied using PCR-restriction fragment length polymorphisms (PCR-RFLPs). Serum lipids were measured by enzymatic kits and apolipoproteins A I, A II, B100, C II, CIII and E were measured by the RID kits.
The frequencies of Ala and Thr allele at Ala54Thr site in obese and non-obese groups were 71.5%, 28.5%, and 71.1%, 28.9%, respectively. No significant difference in the allele frequencies between the two groups was observed (P > 0.05). In the obese group, subjects with Thr allele (AlaThr +ThrThr genotype carriers)had higher serum triglyceride (TG) concentrations than those with genotype AlaAla (P < 0.05). Similar results were observed in obese male subgroup, when male and female subgroups were further separated. In addition, obese males with AlaThr had lower HDL-C levels than those with genotype AlaAla. No significant difference of lipid and apolipoprotein levels was observed in obese females or non-obese group.
The Ala54Thr polymorphism in the FABP2 gene was not associated with obesity in Chinese Han population of Chengdu area. However, it may be associated with serum TG, HDL-C levels, with some gender-specific effect, in this population.
研究中国人群中脂肪酸结合蛋白2基因（FABP2）Ala54Thr多态性及其与肥胖的关系。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLPs）技术对成都地区汉族人群中的393名受试者（272名非肥胖者和121名肥胖者）进行研究。用酶试剂盒测定血脂，用免疫比浊法试剂盒测定载脂蛋白A I、A II、B100、C II、CIII和E。
肥胖组和非肥胖组Ala54Thr位点Ala和Thr等位基因频率分别为71.5%、28.5%和71.1%、28.9%。两组间等位基因频率无显著差异（P>0.05）。在肥胖组中，携带Thr等位基因（AlaThr+ThrThr基因型携带者）的受试者血清甘油三酯（TG）浓度高于AlaAla基因型者（P<0.05）。当进一步分为男性和女性亚组时，肥胖男性亚组也观察到类似结果。此外，携带AlaThr的肥胖男性的高密度脂蛋白胆固醇（HDL-C）水平低于AlaAla基因型者。肥胖女性或非肥胖组的血脂和载脂蛋白水平无显著差异。
成都地区汉族人群中FABP2基因的Ala54Thr多态性与肥胖无关。然而，在该人群中，它可能与血清TG、HDL-C水平有关，且存在一定的性别特异性效应。
