MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Immunology. 2011 May;133(1):1-7. doi: 10.1111/j.1365-2567.2011.03422.x. Epub 2011 Mar 1.
The biochemical properties of the HLA-C antigen differ substantially from those of HLA-A and -B molecules. For this reason, HLA-C diversity and expression at the cell surface are much lower than its counterparts and in consequence HLA-C-restricted responses have been infrequently detected and described. In this review we summarise the key differences between HLA-C and other class I molecules and provide an update on natural killer and T-cell responses restricted by HLA-C. We also discuss the different clinical settings associated with HLA-C alleles which mainly consist of autoimmune disorders, cancers and chronic infections.
HLA-C 抗原的生化特性与 HLA-A 和 -B 分子有很大的不同。因此，HLA-C 在细胞表面的多样性和表达水平要低得多，因此 HLA-C 限制性反应很少被检测和描述。在这篇综述中，我们总结了 HLA-C 与其他 I 类分子之间的关键差异，并提供了关于受 HLA-C 限制的自然杀伤细胞和 T 细胞反应的最新信息。我们还讨论了与 HLA-C 等位基因相关的不同临床情况，这些情况主要包括自身免疫性疾病、癌症和慢性感染。
