Programa de Pós-Graduação em Patologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Av, Antônio Carlos 6627, Belo Horizonte, Minas Gerais, Brasil.
Parasit Vectors. 2011 Feb 28;4:27. doi: 10.1186/1756-3305-4-27.
The influence of inflammation on the number of trophozoites and on the murine amoebic liver abscess area following infection with Entamoeba histolytica and E. dispar was evaluated. Immunohistochemistry and digital morphometry were used to identify and quantify the trophozoites, neutrophils, macrophages, and lesions. Positive correlation was observed between the number of trophozoites and inflammatory cells. A significant decrease in parasitism and inflammation in groups treated with dexamethasone was observed. The scarceness or absence of trophozoites in the treated groups suggest the importance of the inflammatory response in the production of amoebic hepatic abscesses in spite of the inherent virulence of the parasite being decisive in the establishment of the lesion.
研究了炎症对感染溶组织内阿米巴和迪斯帕内阿米巴后滋养体数量和鼠肝阿米巴脓肿面积的影响。使用免疫组织化学和数字形态计量学来鉴定和量化滋养体、中性粒细胞、巨噬细胞和病变。观察到滋养体数量与炎症细胞之间存在正相关。用地塞米松治疗的组中，寄生虫和炎症明显减少。治疗组中滋养体稀少或缺失，表明炎症反应在产生肝阿米巴脓肿中很重要，尽管寄生虫的固有毒力在病变的建立中起决定性作用。
