了解成瘾性疾病。

Understanding the disease of addiction.

作者信息

Detar D Todd

机构信息

Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, Charleston, SC 29425, USA.

出版信息

Prim Care. 2011 Mar;38(1):1-7. doi: 10.1016/j.pop.2010.11.001.

DOI:10.1016/j.pop.2010.11.001

PMID:21356417

Abstract

Addiction is a chronic brain disease. Drug addiction manifests as a compulsive obsession to use a substance despite serious detrimental and sometimes irreversible consequences. Drug addiction is not the same as drug dependency because dependency may not manifest as an addictive behavior. This problem is fundamental to understanding the disease of addiction. This article discusses the neurobiology and genetics of drug addiction.

摘要

成瘾是一种慢性脑部疾病。药物成瘾表现为尽管存在严重的有害影响，有时甚至是不可逆转的后果，仍会对使用某种物质产生强迫性的痴迷。药物成瘾与药物依赖不同，因为依赖可能不会表现为成瘾行为。这个问题对于理解成瘾疾病至关重要。本文将讨论药物成瘾的神经生物学和遗传学。