双功能 SREBF2-miR33a 基因座对脂质动态平衡的调节。
Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus.
机构信息
Laboratory of Physiological Chemistry, de Duve Institute, Université Catholique de Louvain, Avenue Hippocrate 75.39, 1200 Bruxelles, Belgium.
出版信息
Cell Metab. 2011 Mar 2;13(3):241-7. doi: 10.1016/j.cmet.2011.02.004.
Abstract
The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus adding an unexpected layer of complexity and fine-tuning to regulation of lipid homeostasis.
摘要
固醇调节元件结合蛋白-2（SREBF2）基因是一个具有双重功能的基因座，编码 SREBP-2，它是胆固醇生物合成相关基因的一种众所周知的转录调节剂，以及 microRNA-33a，最近的研究表明它可以降低胆固醇输出和脂肪酸β氧化相关蛋白的表达，从而为脂质稳态的调节增加了一个意想不到的复杂和精细的层面。
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