Darling Edward, Thuramalla Naveen, Searles Bruce
Department of Perfusion, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Pediatr Cardiol. 2011 Jun;32(5):585-9. doi: 10.1007/s00246-011-9915-x. Epub 2011 Feb 27.
Novel COstatus system (Transonic Systems, Inc., NY), based on ultrasound dilution (UD), works off in situ arterial and central venous catheters in pediatric patients to measure cardiac output (CO). The purpose of the present study was to validate CO measurement by UD (COUD) with pulmonary artery (PA) thermodilution (COTD) in a prospective animal study. Ten anesthetized pigs (16-45 kg) were instrumented with pediatric PA, central venous, and peripheral artery catheters. For COUD measurements, normothermic saline (0.5-1.0 ml/kg body weight, up to a maximum of 30 ml) was injected into the venous limb of an arteriovenous loop that was connected between in situ catheters. For COTD measurements, 5-10 ml cold saline was injected into the PA catheter. Sixty-four averaged sets were obtained for comparison. COTD mean was 2.98 ± 1.21 l/min (range 1.33-6.29), and COUD mean was 2.68 ± 1.16 l/min (range 1.33-5.85). This study yielded a correlation r = 0.96, COUD = 0.91*(COTD) - 0.04 l/min; bias was 0.3 l/min with limits of agreement as -0.39 to 0.99 l/min; and the percentage error was 23.73% between the methods. CO measurements by UD agreed well with thermodilution measurements in the pediatric swine model.
基于超声稀释法（UD）的新型心输出量监测系统（Transonic Systems公司，纽约），通过小儿患者的原位动脉和中心静脉导管来测量心输出量（CO）。本研究的目的是在前瞻性动物研究中，验证超声稀释法测量心输出量（COUD）与肺动脉热稀释法（COTD）测量结果的一致性。对10只麻醉猪（体重16 - 45千克）植入小儿肺动脉、中心静脉和外周动脉导管。进行COUD测量时，将常温生理盐水（0.5 - 1.0毫升/千克体重，最大30毫升）注入连接原位导管的动静脉环路的静脉端。进行COTD测量时，将5 - 10毫升冷生理盐水注入肺动脉导管。共获得64组平均值用于比较。COTD平均值为2.98±1.21升/分钟（范围1.33 - 6.29），COUD平均值为2.68±1.16升/分钟（范围1.33 - 5.85）。本研究得出相关性r = 0.96，COUD = 0.91×（COTD） - 0.04升/分钟；偏差为0.3升/分钟，一致性界限为 - 0.39至0.99升/分钟；两种方法之间的百分比误差为23.73%。在小儿猪模型中，超声稀释法测量的心输出量与热稀释法测量结果吻合良好。
