• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

使用 123I-碘代托烷 SPET 对伴有精神分裂症的帕金森病患者进行 ECT,并对多巴胺转运体进行可视化。

ECT in a patient with Parkinson's disease and schizophrenia, with dopamine transporter visualisation using 123I-ioflupane SPET.

机构信息

Aguts Unit, Benito Menni Hospital, c/Antoni Pujades s/n. Sant Boi de Llobregat, 08830, Barcelona, Spain.

出版信息

J Neural Transm (Vienna). 2011 Apr;118(4):647-50. doi: 10.1007/s00702-011-0615-8. Epub 2011 Feb 27.

DOI:10.1007/s00702-011-0615-8
PMID:21359970
Abstract

A 58-year old woman with chronic schizophrenia developed worsening parkinsonian symptoms over the previous 6 years, and was eventually diagnosed as having Parkinson's disease. Antipsychotics were stopped because they worsened these symptoms. Antiparkinsonian treatment led to a significant increase in delusions and behavioural disorganisation. The patient underwent electroconvulsive-therapy which improved both her psychiatric and motor symptoms. After treatment, 123I-Ioflupane uptake was mildly increased in the left caudate nucleus, but uptake in right caudate nucleus was lower than in a pretreatment scan.

摘要

一位 58 岁的慢性精神分裂症女性患者,在过去 6 年内出现进行性帕金森病症状,最终被诊断为帕金森病。由于抗精神病药物恶化了这些症状,因此停止了使用。抗帕金森病治疗导致妄想和行为紊乱明显加重。患者接受了电惊厥治疗,改善了她的精神和运动症状。治疗后,123I-Ioflupane 在左侧尾状核的摄取轻度增加,但右侧尾状核的摄取低于治疗前扫描。

相似文献

1
ECT in a patient with Parkinson's disease and schizophrenia, with dopamine transporter visualisation using 123I-ioflupane SPET.使用 123I-碘代托烷 SPET 对伴有精神分裂症的帕金森病患者进行 ECT,并对多巴胺转运体进行可视化。
J Neural Transm (Vienna). 2011 Apr;118(4):647-50. doi: 10.1007/s00702-011-0615-8. Epub 2011 Feb 27.
2
[123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease.[123I]FP - CIT单光子发射计算机断层扫描显示,在早期和晚期帕金森病中,纹状体多巴胺转运体标记明显减少。
J Neurol Neurosurg Psychiatry. 1997 Feb;62(2):133-40. doi: 10.1136/jnnp.62.2.133.
3
Differential patterns of dopamine transporter loss in the basal ganglia of progressive supranuclear palsy and Parkinson's disease: analysis with [(123)I]IPT single photon emission computed tomography.进行性核上性麻痹和帕金森病基底节区多巴胺转运体丧失的差异模式:[(123)I]IPT单光子发射计算机断层扫描分析
J Neurol Sci. 2006 May 15;244(1-2):103-9. doi: 10.1016/j.jns.2006.01.006. Epub 2006 Feb 13.
4
SPECT imaging of the dopamine transporter with [(123)I]-beta-CIT reveals marked decline of nigrostriatal dopaminergic function in Parkinson's disease with urinary dysfunction.使用[(123)I]-β-CIT对多巴胺转运体进行单光子发射计算机断层扫描成像显示,帕金森病合并排尿功能障碍患者黑质纹状体多巴胺能功能显著下降。
J Neurol Sci. 2001 Jun 15;187(1-2):55-9. doi: 10.1016/s0022-510x(01)00521-4.
5
Depressive symptoms in Parkinson's disease are related to reduced [123I]FP-CIT binding in the caudate nucleus.帕金森病患者的抑郁症状与尾状核中 [123I]FP-CIT 结合减少有关。
J Neurol Neurosurg Psychiatry. 2014 Feb;85(2):159-64. doi: 10.1136/jnnp-2012-304811. Epub 2013 Jun 29.
6
Effects of aging and gender on striatal and extrastriatal [123I]FP-CIT binding in Parkinson's disease.衰老和性别对帕金森病纹状体及纹状体以外区域[123I]FP-CIT结合的影响。
Neurobiol Aging. 2015 Apr;36(4):1757-1763. doi: 10.1016/j.neurobiolaging.2015.01.016. Epub 2015 Jan 22.
7
Striatal dopamine transporter abnormalities in patients with essential tremor.原发性震颤患者纹状体多巴胺转运体异常。
Nucl Med Commun. 2008 Apr;29(4):349-53. doi: 10.1097/MNM.0b013e3282f4d307.
8
I-123 DaTscan SPECT Brain Imaging in Parkinsonian Syndromes: Utility of the Putamen-to-Caudate Ratio.I-123 DaTscan SPECT 脑显像在帕金森综合征中的应用:纹状体-尾状核比值的效用。
J Neuroimaging. 2018 Nov;28(6):629-634. doi: 10.1111/jon.12530. Epub 2018 Jun 14.
9
One-day protocol for imaging of the nigrostriatal dopaminergic pathway in Parkinson's disease by [123I]FPCIT SPECT.帕金森病中使用[123I]FPCIT单光子发射计算机断层扫描(SPECT)对黑质纹状体多巴胺能通路进行成像的一日方案。
J Nucl Med. 1999 May;40(5):753-61.
10
Central and peripheral dopamine transporter reduction in Parkinson's disease.帕金森病中中枢和外周多巴胺转运体的减少
Neurol Res. 2009 Sep;31(7):687-91. doi: 10.1179/174313209X383259. Epub 2008 Dec 5.

引用本文的文献

1
Efficacy of Electroconvulsive Therapy for the Treatment of Movement Disorders: A Literature Review.电休克治疗对运动障碍的疗效:文献综述
Cureus. 2023 Mar 24;15(3):e36634. doi: 10.7759/cureus.36634. eCollection 2023 Mar.
2
Cerebrospinal Fluid Proteomics For Identification Of α2-Macroglobulin As A Potential Biomarker To Monitor Pharmacological Therapeutic Efficacy In Dopamine Dictated Disease States Of Parkinson's Disease And Schizophrenia.脑脊液蛋白质组学用于鉴定α2-巨球蛋白作为一种潜在生物标志物,以监测帕金森病和精神分裂症多巴胺主导疾病状态下的药物治疗效果。
Neuropsychiatr Dis Treat. 2019 Oct 2;15:2853-2867. doi: 10.2147/NDT.S214217. eCollection 2019.
3

本文引用的文献

1
Electroconvulsive therapy alters dopamine signaling in the striatum of non-human primates.电抽搐疗法改变了非人类灵长类动物纹状体中的多巴胺信号传递。
Neuropsychopharmacology. 2011 Jan;36(2):511-8. doi: 10.1038/npp.2010.182. Epub 2010 Oct 13.
2
Increased striatal dopamine transporter levels, as indicated by a DAT scan, induced by ziprasidone in association to improvement of tardive dyskinesia--a case report.齐拉西酮诱导纹状体多巴胺转运体水平升高(由DAT扫描显示),与迟发性运动障碍改善相关——病例报告
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1135-6. doi: 10.1016/j.pnpbp.2010.05.001. Epub 2010 May 10.
3
2D-DIGE as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine-dictated states of Parkinson's disease and schizophrenia.
二维差异凝胶电泳作为一种识别血清蛋白生物标志物的策略,用于监测帕金森病和精神分裂症多巴胺主导状态下的药理疗效。
Neuropsychiatr Dis Treat. 2019 Apr 24;15:1031-1044. doi: 10.2147/NDT.S198559. eCollection 2019.
4
Evaluation of Serum Apolipoprotein E as a Potential Biomarker for Pharmacological Therapeutic Efficacy Monitoring in Dopamine Dictated Disease Spectrum of Schizophrenia and Parkinson's disease: A Preliminary Study.血清载脂蛋白E作为精神分裂症和帕金森病多巴胺主导疾病谱中药理学治疗疗效监测潜在生物标志物的评估:一项初步研究。
J Cent Nerv Syst Dis. 2018 Oct 9;10:1179573518803585. doi: 10.1177/1179573518803585. eCollection 2018.
5
Antidepressant treatment effects on dopamine transporter availability in patients with major depression: a prospective I-FP-CIT SPECT imaging genetic study.抗抑郁治疗对重性抑郁症患者多巴胺转运体可利用度的影响:一项前瞻性 I-FP-CIT SPECT 成像遗传学研究。
J Neural Transm (Vienna). 2018 Jun;125(6):995-1005. doi: 10.1007/s00702-018-1863-7. Epub 2018 Feb 23.
6
Elevated dopamine D1 receptor availability in striatum of Göttingen minipigs after electroconvulsive therapy.电抽搐治疗后哥廷根小型猪纹状体中多巴胺 D1 受体可用性升高。
J Cereb Blood Flow Metab. 2018 May;38(5):881-887. doi: 10.1177/0271678X17705260. Epub 2017 May 16.
Signs of striatal dopamine transporter density increase in association with improvement of tardive dyskinesia in a patient with schizophrenia, as demonstrated by a DAT scan.
一项多巴胺转运蛋白扫描(DAT 扫描)显示,精神分裂症患者的纹状体多巴胺转运体密度增加,与迟发性运动障碍改善相关。
Eur Neuropsychopharmacol. 2010 Feb;20(2):132-6. doi: 10.1016/j.euroneuro.2009.08.002. Epub 2009 Sep 8.
4
Accuracy of DaTSCAN (123I-Ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2-year follow-up of an open-label study.DaTSCAN(123I-碘氟烷)单光子发射计算机断层扫描在临床诊断不明确的帕金森综合征患者诊断中的准确性:一项开放标签研究的2年随访
Mov Disord. 2007 Dec;22(16):2346-51. doi: 10.1002/mds.21710.
5
[Diagnostic accuracy of FP-CIT SPECT in patients with parkinsonism].[氟哌啶醇摄取脑单光子发射计算机断层扫描在帕金森综合征患者中的诊断准确性]
Rev Esp Med Nucl. 2007 Sep-Oct;26(5):277-85.
6
Action of novel antipsychotics at human dopamine D3 receptors coupled to G protein and ERK1/2 activation.新型抗精神病药物对与G蛋白偶联及ERK1/2激活的人多巴胺D3受体的作用。
Neuropharmacology. 2007 Aug;53(2):232-41. doi: 10.1016/j.neuropharm.2007.05.006. Epub 2007 May 21.
7
Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats.电惊厥休克增强6-羟基多巴胺损伤大鼠纹状体多巴胺D1和D3受体结合并改善运动性能。
J Psychiatry Neurosci. 2007 May;32(3):193-202.
8
Dopaminergic dysbalance in distinct basal ganglia neurocircuits: implications for the pathophysiology of Parkinson's disease, schizophrenia and attention deficit hyperactivity disorder.不同基底神经节神经回路中的多巴胺能失衡:对帕金森病、精神分裂症和注意力缺陷多动障碍病理生理学的影响。
Neurotox Res. 2006 Dec;10(3-4):167-79. doi: 10.1007/BF03033354.
9
Lower striatal dopamine transporter binding in neuroleptic-naive schizophrenic patients is not related to antipsychotic treatment but it suggests an illness trait.未服用过抗精神病药物的精神分裂症患者纹状体多巴胺转运体结合水平较低,这与抗精神病治疗无关,但提示这是一种疾病特征。
Psychopharmacology (Berl). 2007 Apr;191(3):805-11. doi: 10.1007/s00213-006-0570-5. Epub 2006 Sep 22.
10
D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia.精神分裂症患者丘脑和皮质中[F-18]氟哌利多与D2/D3多巴胺受体的结合情况。
Schizophr Res. 2006 Jul;85(1-3):232-44. doi: 10.1016/j.schres.2006.03.042. Epub 2006 May 19.