Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan.
J Neurol. 2011 Aug;258(8):1464-8. doi: 10.1007/s00415-011-5960-x. Epub 2011 Mar 1.
Total tau protein (t-tau) levels in cerebrospinal fluid (CSF) (CSF-tau) are markedly elevated in patients with Creutzfeldt-Jakob disease (CJD). Some CSF-tau may leak into the blood. We evaluated t-tau levels in serum (serum-tau) as a possible marker for the differential diagnosis of CJD from Alzheimer's disease (AD) and other rapidly progressive dementias (RPD). Serum- and CSF-tau levels were determined in patients with sporadic CJD (n = 12), AD (n = 10) and RPD but no CJD (non-CJD-RPD; n = 9) who showed RPD fulfilling the World Health Organization (WHO) criteria for possible CJD at onset and had a final diagnosis other than CJD. We also analyzed serum-tau levels in healthy volunteers as a control group (n = 10). Serum- as well as CSF-tau levels were significantly elevated in CJD group compared to those in AD, non-CJD-RPD and healthy control groups. Serum-tau would be a simple and useful marker to distinguish CJD from AD and non-CJD-RPD, requiring further large study to confirm this.
脑脊髓液（CSF）中的总 tau 蛋白（t-tau）水平在克雅氏病（CJD）患者中明显升高。一些 CSF-tau 可能会渗漏到血液中。我们评估了血清中的 t-tau 水平（血清-tau），作为将 CJD 与阿尔茨海默病（AD）和其他快速进展性痴呆（RPD）进行鉴别诊断的可能标志物。我们测定了散发性 CJD（n = 12）、AD（n = 10）和非 CJD-RPD（n = 9）患者的血清和 CSF-tau 水平，这些患者的 RPD 符合世界卫生组织（WHO）关于可能的 CJD 的标准，且在发病时具有除 CJD 以外的其他最终诊断。我们还分析了健康志愿者的血清-tau 水平作为对照组（n = 10）。与 AD、非 CJD-RPD 和健康对照组相比，CJD 组的血清和 CSF-tau 水平明显升高。血清-tau 是一种简单而有用的标志物，可用于区分 CJD 与 AD 和非 CJD-RPD，需要进一步的大规模研究来证实这一点。
