Hamaguchi Tsuyoshi, Noguchi-Shinohara Moeko, Nozaki Ichiro, Nakamura Yosikazu, Sato Takeshi, Kitamoto Tetsuyuki, Mizusawa Hidehiro, Yamada Masahito
Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Emerg Infect Dis. 2009 Feb;15(2):265-71. doi: 10.3201/eid1502.080749.
To elucidate the association between medical procedures and sporadic Creutzfeldt-Jakob disease (sCJD), we analyzed medical procedures (any surgical procedure, neurosurgery, ophthalmic surgery, and blood transfusion) for patients registered by the CJD Surveillance Committee in Japan during 1999-2008. We conducted an age-stratified case-control study with 753 sCJD patients and 210 controls and a study of patients who underwent neurosurgical or ophthalmic surgical procedures at the same hospital. Although the control group was relatively small, no evidence was found that prion disease was transmitted through the investigated medical procedures before onset of sCJD. After onset of sCJD, 4.5% of the sCJD patients underwent operations, including neurosurgical for 0.8% and ophthalmic for 1.9%; no special precautions against transmission of prion diseases were taken. Fortunately, we have not identified patients with prion disease attributed to these operations. Our findings indicate that surgical procedures or blood transfusion had little effect on the incidence of sCJD.
为阐明医疗程序与散发性克雅氏病（sCJD）之间的关联，我们分析了1999年至2008年期间日本克雅氏病监测委员会登记的患者所接受的医疗程序（任何外科手术、神经外科手术、眼科手术和输血）。我们进行了一项年龄分层的病例对照研究，纳入753例sCJD患者和210例对照，并对在同一家医院接受神经外科或眼科手术的患者进行了研究。尽管对照组相对较小，但未发现有证据表明朊病毒病在sCJD发病前通过所调查的医疗程序传播。sCJD发病后，4.5%的sCJD患者接受了手术，其中0.8%为神经外科手术，1.9%为眼科手术；未采取针对朊病毒病传播的特殊预防措施。幸运的是，我们尚未发现因这些手术导致朊病毒病的患者。我们的研究结果表明，外科手术或输血对sCJD的发病率影响很小。
