Saxena D K, Murthy R C, Lal B, Srivastava R S, Chandra S V
Neurotoxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Reprod Toxicol. 1990;4(3):223-8. doi: 10.1016/0890-6238(90)90062-z.
Daily intraperitoneal administration of hexavalent chromium (Cr6+; 1, 2, and 3 mg/kg intraperitoneally as potassium dichromate) in weaned rats for an entire duration of 55 and 90 days of age produced dose- and duration-dependent enzymatic and pathologic alterations. At 55 days, the pathologic changes were not seen in testes of Cr6+ treated rats, but the activities of sorbitol dehydrogenase, lactic dehydrogenase, gamma-glutamyl transpeptidase, and glucose-6-phosphate dehydrogenase were significantly altered. When the treatment was prolonged to sexual maturity, that is, 90 days of age, the alterations in enzyme activities were greater, and there were dose-dependent pathologic changes in the testes of Cr(6+)-treated rats. These alterations suggest a risk to growing testes if rats are exposed to Cr6+ during the prepubertal stage of development, which, in turn, may disturb normal testicular physiology at adulthood.
在断奶大鼠55日龄至90日龄期间，每日腹腔注射六价铬（Cr6+；以重铬酸钾形式腹腔注射，剂量为1、2和3 mg/kg），会产生剂量和时间依赖性的酶学及病理学改变。在55日龄时，Cr6+处理组大鼠的睾丸未见病理学变化，但山梨醇脱氢酶、乳酸脱氢酶、γ-谷氨酰转肽酶和葡萄糖-6-磷酸脱氢酶的活性发生了显著改变。当处理延长至性成熟阶段，即90日龄时，酶活性的改变更大，且Cr(6+)处理组大鼠的睾丸出现了剂量依赖性的病理学变化。这些改变表明，如果大鼠在青春期前发育阶段暴露于Cr6+，对正在生长的睾丸存在风险，进而可能扰乱成年期的正常睾丸生理功能。
