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基于物质粗糙集理论的中药缓释制剂“总量”释放动力学评价

["Total amount" release kinetics evaluation of traditional Chinese medicine sustained-release preparations based on material rough set theory].

作者信息

Yue Peng-Fei, Zheng Qin, Zhu Gen-Hua, Wu Zhen-Feng, Hu Peng-Yi, Yang Ming

机构信息

Key Lab of Modern Preparation of Traditional Chinese Medicine, Ministry ofEducation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.

出版信息

Yao Xue Xue Bao. 2010 Nov;45(11):1354-60.

Abstract

The release kinetics research of sustained-release formulations of traditional Chinese medicines (TCM) is an inalienable part of the chain of TCM modernization, which plays an important role in the development of modern compound TCM preparation. However, the research method or pattern in line with the specific characteristics of TCM, i.e., multi-component and multi-target, is still lacking. On the basis of material rough set theory, this paper reviewed the advantages and disadvantages of the existing evaluation patterns and methods, a tentative idea about the "total amount" release characteristics evaluation on TCM compound sustained-release preparation has suggested so as to evaluate the release kinetics and to promote the development of evaluation methodology on TCM sustained-release preparations.

摘要

中药缓释制剂的释放动力学研究是中药现代化链条中不可或缺的一部分,在现代复方中药制剂的发展中发挥着重要作用。然而,目前仍缺乏符合中药多组分、多靶点这一特性的研究方法或模式。基于物质粗集理论,本文综述了现有评价模式和方法的优缺点,提出了关于中药复方缓释制剂“总量”释放特性评价的初步构想,以期对释放动力学进行评价,推动中药缓释制剂评价方法学的发展。

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