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[Isolation and identification of impurities from raw material of clindamycin phosphate].

作者信息

Li Yue, Wu Tong, Chen Shu-Zeng, Sun Qiu-Shi, Qin Li, Xu Ling-Yue

机构信息

Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.

出版信息

Yao Xue Xue Bao. 2010 Nov;45(11):1415-20.

PMID:21361042
Abstract

Four impurities were isolated from raw material of clindamycin phosphate (CP), and their structures have been determined. LC-MS was used to determine the molecular weights of the impurities in the raw material of CP. Reversed-phase preparative HPLC was used to prepare them, and their chemical structures were identified by HR-MS and NMR. The four unknown impurities were determined as clindamycin-B-phosphate (1), clindamycin-2,4-diphosphate (2), 3',6'-dehydro clindamycin phosphate (3), epi-clindamycin phosphate (4). Impurity 1 has been included in BP and EP, while 2, 3 and 4 have not. The impurities 2, 3, 4 are first separated from raw material of CP.

摘要

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