3rd Clinical Hospital, Jilin University, Changchun 130033, China.
J Biomed Nanotechnol. 2010 Dec;6(6):683-6. doi: 10.1166/jbn.2010.1165.
In this paper, we present the preparation and characterization of organic dye-coated magnetic particles and its application as magnetic resonance imaging (MRI) and photodynamic therapy (PDT) agent. We have coated the surface of Fe3O4 magnetic nanoparticles by meso-tetra(4-sulfonatophenyl) porphyrin dihydrochloride (TSPP), a photosensitive drug used in PDT, which is capable of generating singlet oxygen on the surface of paramagnetic Fe3O4 nanoparticles when irradiated at 400 nm. While the MRI was performed with in vivo mice experiment along with proper irradiation and therapeutic effect was followed by using in-situ MRI technology. The resulting conjugate is a single particle platform that can simultaneously be used as a PDT therapeutic and MRI contrasting agent.
本文介绍了有机染料包覆磁性粒子的制备和表征及其在磁共振成像（MRI）和光动力治疗（PDT）中的应用。我们通过介孔四（4-磺酸钠苯基）卟啉二盐酸盐（TSPP）包覆了 Fe3O4 磁性纳米粒子的表面，TSPP 是一种用于 PDT 的光敏药物，当用 400nm 光照射时，它能够在顺磁性 Fe3O4 纳米粒子的表面产生单重态氧。同时，通过体内小鼠实验进行了 MRI 检测，并且利用原位 MRI 技术对适当的辐照和治疗效果进行了跟踪。所得的缀合物是一种单颗粒平台，可同时用作 PDT 治疗剂和 MRI 对比剂。
