Caractéristation du Tissu Osseux par Imagerie, U658 Inserm, Orleans, France.
Med Phys. 2011 Jan;38(1):420-8. doi: 10.1118/1.3528125.
Hip fracture is a serious health problem and textural methods are being developed to assess bone quality. The authors aimed to perform textural analysis at femur on high-resolution digital radiographs compared to three-dimensional (3D) microarchitecture comparatively to bone mineral density.
Sixteen cadaveric femurs were imaged with an x-ray device using a C-MOS sensor. One 17 mm square region of interest (ROI) was selected in the femoral head (FH) and one in the great trochanter (GT). Two-dimensional (2D) textural features from the co-occurrence matrices were extracted. Site-matched measurements of bone mineral density were performed. Inside each ROI, a 16 mm diameter core was extracted. Apparent density (Dapp) and bone volume proportion (BV/TV(Arch)) were measured from a defatted bone core using Archimedes' principle. Microcomputed tomography images of the entire length of the core were obtained (Skyscan 1072) at 19.8 microm of resolution and usual 3D morphometric parameters were computed on the binary volume after calibration from BV/TV(Arch). Then, bone surface/bone volume, trabecular thickness, trabecular separation, and trabecular number were obtained by direct methods without model assumption and the structure model index was calculated.
In univariate analysis, the correlation coefficients between 2D textural features and 3D morphological parameters reached 0.83 at the FH and 0.79 at the GT. In multivariate canonical correlation analysis, coefficients of the first component reached 0.95 at the FH and 0.88 at the GT.
Digital radiographs, widely available and economically viable, are an alternative method for evaluating bone microarchitectural structure.
髋部骨折是一个严重的健康问题，目前正在开发纹理方法来评估骨质量。作者旨在比较三维（3D）微结构与骨密度，对高分辨率数字射线照片上的股骨进行纹理分析。
使用 C-MOS 传感器的 X 射线设备对 16 具尸体股骨进行成像。在股骨头（FH）和大转子（GT）中选择一个 17mm 见方的感兴趣区域（ROI）。从共生矩阵中提取二维（2D）纹理特征。在每个 ROI 内，提取一个 16mm 直径的核心。使用阿基米德原理从脱脂骨芯中测量表观密度（Dapp）和骨体积比（BV/TV(Arch)）。使用 Skyscan 1072 获得整个骨芯长度的微计算机断层扫描图像（分辨率为 19.8μm），并在经过从 BV/TV(Arch)校准的二进制体积上计算常规 3D 形态计量参数。然后，通过直接方法而无需模型假设，获得骨表面/骨体积、小梁厚度、小梁间距和小梁数量，并计算结构模型指数。
在单变量分析中，FH 处 2D 纹理特征与 3D 形态参数之间的相关系数达到 0.83，GT 处达到 0.79。在多元典型相关分析中，第一分量的系数在 FH 处达到 0.95，在 GT 处达到 0.88。
数字射线照片广泛可用且经济可行，是评估骨微观结构的替代方法。
