Ito M, Nakamura T, Matsumoto T, Tsurusaki K, Hayashi K
Department of Radiology, Nagasaki University, Sakamoto, Japan.
Bone. 1998 Aug;23(2):163-9. doi: 10.1016/s8756-3282(98)00083-0.
Iliac bone samples were obtained from 50 women with osteoarthrosis of the hip (50-80 years of age) during hip surgery for total hip joint replacement. After determining the resolution and threshold for the binary image, the two-dimensional (2D) and three-dimensional (3D) data of the trabecular structure were obtained in these iliac bone samples using microcomputed tomography (micro-CT). Conventional histomorphometry was then performed. Both 2D and 3D parameters of the trabecular structure were significantly correlated with the parameters of conventional histomorphometry (r = 0.63-0.86 in 2D analysis, and r = 0.60-0.77 in 3D analysis). The patients were classified into the non-spinal-fracture group (n = 36) and the spinal fracture group (n = 14). There was no significant difference in patient age between the two groups. The parameter values of bone mass, such as 2D fractional trabecular bone area and 3D fractional bone volume, and the values of trabecular number (Tb.N) in terms of both 2D and 3D analyses were significantly smaller, and those of trabecular separation (Tb.Sp) were significantly higher in the spinal fracture group than in the non-spinal-fracture group. Trabecular thickness (Tb.Th) values did not significantly differ between the two groups. There was no significant difference between 2D and 3D parameters in discriminating the spinal fracture group from the non-spinal-fracture group. However, 3D analysis demonstrated that the value of the bone surface to bone volume (BS/BV) ratio could discriminate between these two groups. These data demonstrated that micro-CT can evaluate the 3D structure of the human iliac bone, and that decreases in the parameters of the 3D-structure-related bone surface density as well as decreases in trabecular bone volume are related to osteoporotic fracture.
在全髋关节置换手术中，从50名患有髋骨关节炎的女性（年龄在50 - 80岁之间）获取髂骨样本。在确定二值图像的分辨率和阈值后，使用微型计算机断层扫描（micro-CT）在这些髂骨样本中获取小梁结构的二维（2D）和三维（3D）数据。然后进行传统组织形态计量学分析。小梁结构的2D和3D参数均与传统组织形态计量学参数显著相关（2D分析中r = 0.63 - 0.86，3D分析中r = 0.60 - 0.77）。将患者分为非脊柱骨折组（n = 36）和脊柱骨折组（n = 14）。两组患者年龄无显著差异。脊柱骨折组的骨量参数值，如2D小梁骨面积分数和3D骨体积分数，以及2D和3D分析中的小梁数量（Tb.N）值均显著较小，而小梁间距（Tb.Sp）值则显著高于非脊柱骨折组。两组之间的小梁厚度（Tb.Th）值无显著差异。在区分脊柱骨折组和非脊柱骨折组方面，2D和3D参数之间无显著差异。然而，3D分析表明，骨表面积与骨体积（BS/BV）比值可区分这两组。这些数据表明，micro-CT可以评估人髂骨的3D结构，并且与3D结构相关的骨表面密度参数的降低以及小梁骨体积的减少与骨质疏松性骨折有关。
