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蒙特卡罗研究电荷传输效应对用于 SPECT/PET 应用的像素化 CZT 探测器的能量分辨率和检测效率的影响。

Monte Carlo investigation of charge-transport effects on energy resolution and detection efficiency of pixelated CZT detectors for SPECT/PET applications.

机构信息

Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom.

出版信息

Med Phys. 2011 Jan;38(1):455-67. doi: 10.1118/1.3532825.

Abstract

PURPOSE

Semiconductor detectors are increasingly considered as alternatives to scintillation crystals for nuclear imaging applications such as positron emission tomography (PET) or single photon emission computed tomography (SPECT). One of the most prominent detector materials is cadmium zinc telluride (CZT), which is currently used in several application-specific nuclear imaging systems. In this work, the charge-transport effects in pixelated CZT detectors in relation to detector pixel size and thickness are investigated for pixels sizes from 0.4 up to 1.6 mm.

METHODS

The determination of an optimum pixel size and thickness for use with photon energies of 140 and 511 keV, suitable for SPECT and PET studies, is attempted using photon detection efficiency and energy resolution as figures of merit. The Monte Carlo method combined with detailed finite element analysis was utilized to realistically model photon interactions in the detector and the signal generation process. The GEANT4 Application for Tomographic Emission (GATE) toolkit was used for photon irradiation and interaction simulations. The COMSOL MULTIPHYSICS software application was used to create finite element models of the detector that included charge drift, diffusion, trapping, and generation. Data obtained from the two methods were combined to generate accurate signal induction at the detector pixels. The energy resolution was calculated as the full width at half maximum of the energy spectrum photopeak. Photon detection efficiency was also calculated. The effects of charge transport within the detector and photon escape from primary pixel of interaction were investigated; the extent of diffusion to lateral pixels was also assessed.

RESULTS

Charge transport and signal induction were affected by the position of a pixel in the detector. Edge and corner pixels were less susceptible to lateral diffusion than pixels located in the inner part of the detector. Higher detection efficiency and increased photon escape from primary interaction pixel were observed for thicker detectors. Energy resolution achieved better values in 0.7 and 1.0 mm pixel size for 5 mm detector thickness and 1.6 mm pixel size for 10 mm thickness.

CONCLUSIONS

Selection of pixel size and thickness depends on the imaging application and photon energy utilized. For systems that integrate two nuclear imaging modalities (i.e., combined SPECT/PET), the pixel size should offer an appropriate balance of the effects that take place in the detector, based on the results of the current work. This allows for a system to be designed with the same detector material and the same geometrical configuration for both modalities.

摘要

目的

半导体探测器越来越多地被认为是放射性成像应用(如正电子发射断层扫描(PET)或单光子发射计算机断层扫描(SPECT))中闪烁晶体的替代物。最突出的探测器材料之一是碲化镉锌(CZT),它目前用于几种专用核成像系统中。在这项工作中,研究了像素化 CZT 探测器的电荷传输效应与探测器像素大小和厚度的关系,像素尺寸从 0.4 毫米到 1.6 毫米不等。

方法

尝试使用光子探测效率和能量分辨率作为衡量标准,确定适用于 140 和 511keV 光子能量的最佳像素大小和厚度,适用于 SPECT 和 PET 研究。利用蒙特卡罗方法结合详细的有限元分析,对探测器中的光子相互作用和信号产生过程进行了真实的建模。GEANT4 应用于发射断层扫描(GATE)工具包用于光子辐照和相互作用模拟。COMSOL MULTIPHYSICS 软件应用程序用于创建包括电荷漂移、扩散、俘获和产生的探测器的有限元模型。从这两种方法获得的数据结合起来,在探测器像素处产生准确的信号感应。能量分辨率被计算为能谱光电峰的半高全宽。还计算了光子探测效率。研究了探测器内电荷传输和光子从初级相互作用像素逸出的影响;还评估了扩散到横向像素的程度。

结果

电荷传输和信号感应受到探测器中像素位置的影响。边缘和角像素比位于探测器内部的像素更不易受到横向扩散的影响。对于较厚的探测器,观察到更高的检测效率和从初级相互作用像素逸出的更多光子。在 5 毫米探测器厚度的 0.7 和 1.0 毫米像素尺寸以及 10 毫米厚度的 1.6 毫米像素尺寸下,实现了更好的能量分辨率值。

结论

像素尺寸和厚度的选择取决于成像应用和所使用的光子能量。对于集成两种核成像模式(即,组合 SPECT/PET)的系统,根据当前工作的结果,像素尺寸应在探测器中发生的各种影响之间提供适当的平衡。这允许使用相同的探测器材料和相同的几何配置为两种模式设计系统。

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