Department of Neurological Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 17103, USA.
Neurosurg Focus. 2011 Mar;30(3):E15. doi: 10.3171/2011.1.FOCUS10266.
Ossification of the ligamentum flavum (OLF) is a disease of ectopic bone formation within the ligamentum flavum, which may result in mass effect and neurological compromise. The low thoracic region is the most common region of occurrence, and this is followed by the cervical, then lumbar, spine. The prevalence of OLF is significantly higher in the Japanese population compared with other nationalities and has a male preponderance. Ossification of the ligamentum flavum has been reported in association with the more common ligamentous pathological entities--ossification of the posterior longitudinal ligament and diffuse idiopathic skeletal hyperostosis. These latter two conditions have been linked to several metabolic processes, and a possible genetic basis has been hypothesized. Here, the authors present a unique case of OLF of the cervical spine in a patient with idiopathic hypercalcemia.
黄韧带骨化（OLF）是黄韧带内异位骨形成的一种疾病，可能导致肿块效应和神经功能障碍。胸段下部是最常见的发病部位，其次是颈段，然后是腰段。与其他民族相比，日本人中 OLF 的患病率明显更高，且男性居多。OLF 与更常见的韧带病理实体——后纵韧带骨化和弥漫性特发性骨肥厚有关。后两种情况与几种代谢过程有关，并假设存在可能的遗传基础。在这里，作者报告了一例伴有特发性高钙血症的颈椎 OLF 患者的独特病例。
