Du Pasquier L, Flajnik M F
Basel Institute for Immunology, Switzerland.
Dev Immunol. 1990;1(2):85-95. doi: 10.1155/1990/67913.
Larval and adult forms of the amphibian Xenopus differ in their MHC class II expression. In tadpoles, class II epitopes can be detected by monoclonal antibodies only on B cells, macrophages (whatever their location), spleen reticulum, thymus epithelium, and the pharyngobuccal cavity. In contrast, all adult T cells express class II on their surface. The transitions in class II expression occur at metamorphosis and are accompanied by other changes. The skin is invaded by class II positive dendritic cells, and the skin glands differentiate and also express class II. The gut, which expressed class II in discrete areas of the embryonic tissue, becomes invaded with B cells, and its epithelium also becomes class II positive.
两栖动物非洲爪蟾的幼体和成体在其MHC II类分子表达上存在差异。在蝌蚪中，II类表位仅能通过单克隆抗体在B细胞、巨噬细胞（无论其位置）、脾脏网状组织、胸腺上皮以及咽颊腔中检测到。相比之下，所有成年T细胞表面都表达II类分子。II类分子表达的转变发生在变态期，并且伴随着其他变化。皮肤被II类阳性树突状细胞侵入，皮肤腺分化并也表达II类分子。在胚胎组织的离散区域表达II类分子的肠道，被B细胞侵入，其上皮也变为II类阳性。
