Kollmer W E
Gesellschaft für Strahlen- und Umweltforschung GmbH, Institut für Strahlenbiologie, Neuherberg, Fed. Rep. of Germany.
J Trace Elem Electrolytes Health Dis. 1990 Jun;4(2):79-85.
Induced hair of the rat was used in well-controlled standardized experiments to examine the reliability of hair analysis as an indicator of arsenic ingestion and internal exposure. A clear dose response was established for single doses between 50 micrograms and 5 mg corresponding to doses per kg body weight of 130 micrograms to 13 mg. In the range of high doses this dose response in the rat was about ten times lower than that found in man. The transfer of endogenous arsenic was only observed in growing, not in resting hair. Endogenous arsenic in hair was not removed by mild preanalytical washing. The amount found in hair growing within 10 or 12 days after the single dose or the start of treatments was the same regardless of whether the dose had been administered in one intubation or it had been split into ten treatments. After the very efficient transfer observed for a relatively short time following ingestion of the element, a sharp decrease in As content of the hair was observed despite a persisting load within the major organs.
在严格控制的标准化实验中，使用大鼠的诱导毛发来检验毛发分析作为砷摄入和体内暴露指标的可靠性。对于50微克至5毫克的单次剂量（相当于每千克体重130微克至13毫克的剂量），建立了明确的剂量反应关系。在高剂量范围内，大鼠的这种剂量反应比人类低约十倍。内源性砷的转移仅在生长毛发中观察到，而在静止毛发中未观察到。毛发中的内源性砷不会因轻度分析前清洗而去除。单次给药或开始治疗后10天或12天内生长的毛发中发现的砷含量相同，无论剂量是通过一次插管给药还是分成十次给药。在摄入该元素后相对较短的时间内观察到非常有效的转移后，尽管主要器官内持续有负荷，但毛发中的砷含量仍急剧下降。
