Kollmer W E
GSF, Institut für Strahlenbiologie, Neuherberg, Fed. Rep. of Germany.
J Trace Elem Electrolytes Health Dis. 1992 Mar;6(1):11-4.
The behaviour of the rate of transfer of arsenic to hair induced at various times during a long-term exposure experiment was examined in rats supplied with 3 mg arsenic per litre of drinking water in the form of chloride. The arsenic was supplied during a period of 560 days. At the beginning a sharp increase was seen in the rate of transfer of arsenic to induced hair, as well as in the content of arsenic in the various organs. Subsequently, the rate of transfer to hair increased slowly but steadily up to the end of the experiment. During that time the level of arsenic in the liver and in the kidneys remained constant, whereas that in the brain and in some other organs increased slowly and irregularly. The correlation between the arsenic in the induced hair and that in the organs was statistically significant in all comparisons. Correlation coefficients greater than 0.7 were found in the comparisons of the content in the induced hair with those in the heart, the pancreas and the forebrain. The findings suggest that the rate of transfer of endogenous arsenic depends on two factors, one being the level of body intake of arsenic during the period of hair growth, the other the degree to which the element had accumulated in the body during the time which elapsed between the onset of arsenic supply and the start of hair growth.
在长期暴露实验的不同时间点，对以氯化物形式在每升饮用水中添加3毫克砷的大鼠体内砷向毛发转移速率的行为进行了研究。砷的供应持续了560天。实验开始时，砷向新生毛发的转移速率以及各器官中的砷含量均急剧增加。随后，直至实验结束，砷向毛发的转移速率缓慢但稳定地上升。在此期间，肝脏和肾脏中的砷含量保持恒定，而大脑和其他一些器官中的砷含量则缓慢且不规则地增加。在所有比较中，新生毛发中的砷与各器官中的砷之间的相关性具有统计学意义。在新生毛发与心脏、胰腺和前脑的砷含量比较中，发现相关系数大于0.7。研究结果表明，内源性砷的转移速率取决于两个因素，一个是毛发生长期间体内砷的摄入量，另一个是从开始供应砷到毛发生长开始这段时间内该元素在体内的积累程度。
